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Yes, blood tests measuring specific antibodies can indicate celiac disease. While a biopsy is the gold standard for diagnosis, positive antibody results, along with symptoms and genetic testing, can support a diagnosis without a biopsy.
Genetic testing is not mandatory for diagnosis but can be helpful. It identifies the presence of HLA-DQ2 or HLA-DQ8 genes associated with celiac disease. However, genetic testing alone does not confirm or rule out the disease as many individuals with these genes may not develop celiac disease.
Yes, it is possible. Serology tests detect specific antibodies, but false negatives can occur, especially if the individual has started a gluten-free diet before testing. If suspicion of celiac disease remains despite negative results, further testing or a gluten challenge may be necessary for an accurate diagnosis.
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