What is peptic ulcer disease?

Peptic ulcer disease is a condition characterized by the formation of open sores (ulcers) in the lining of the stomach or the upper part of the small intestine. These ulcers develop as a result of an imbalance between stomach acid and protective factors, such as mucus production. Common causes include infection with Helicobacter pylori bacteria, use of nonsteroidal anti-inflammatory drugs (NSAIDs), and excessive acid production.