Cold Agglutinins Test For Cold Agglutinin-Related Anemia

Cold Agglutinins Test For Cold Agglutinin-Related Anemia

The Cold Agglutinins Test is a blood test that helps identify autoimmune antibodies that affect red blood cells when exposed to cold. It's used to diagnose a rare condition called Cold Agglutinin Disease, which can lead to anemia and symptoms like fatigue and pain in cold temperatures.

 

Cold Agglutinins Test

Here are the basic details of the Cold Agglutinins Test.

Also Known As Cold Agglutinin Blood Test
Type Blood Test
Purpose Diagnose Cold Agglutinin Disease and hemolytic anemia.
Sample Type Serum
Preparation No
Fasting Not required
Gender Unisex
Age Group All
Normal Value 1:64 or 1:512
Reporting Time A few days
Cost 300-800 INR*

*Cold Agglutinins Test Price range may vary as per location, lab type, and procedure of lab test.

 

Cold Agglutinins Test Means

Cold Agglutinins Test is a diagnostic blood test that detects autoimmune antibodies affecting red blood cells when exposed to cold temperatures.

  • It's used to diagnose Cold Agglutinin Disease, a rare condition causing anemia and cold-related symptoms.
  • Results of the test are reported as a titer, such as 1:64 or 1:512, indicating the level of cold agglutinins in the blood.
  • The test is applicable to individuals of all genders and age groups and does not require specific gender or age considerations.

 

Cold Agglutinins Test Purpose

The purpose of the Cold Agglutinins Test is to:

  • Diagnose Cold Agglutinin Disease, an autoimmune disorder.
  • Identify autoimmune antibodies impacting red blood cells.
  • Determine the cause of anemia and associated symptoms.
  • Assess the impact of cold exposure on red blood cells.
  • Aid in managing and treating cold-related anemia conditions.

Cold Agglutinins  Test_ Price, Normal Range, Result, Purpose, Procedure Meaning and Interpretation - Drlogy Test

 

Cold Agglutinins Test Preparation

Here is the basic preparation for the Cold Agglutinins Test.

 

Before Test

  • No specific fasting or dietary restrictions are required.
  • Inform your healthcare provider about any medications that might affect the test.
  • Ensure you are adequately hydrated.

 

During Test

  • A blood sample is taken from a vein in your arm using a needle.
  • You may experience a brief needle prick and some mild discomfort.
  • Follow any instructions or requests from the healthcare provider.

 

After Test

  • You can resume normal activities immediately.
  • Minor bruising or soreness at the site is common and should subside quickly.
  • Await the test results, which may take a few days, as advised by your healthcare provider.

 

Cold Agglutinins Test Procedure

Here is the basic Cold Agglutinins Test Procedure.

  • A blood sample is drawn from a vein in your arm.
  • The sample is sent to a laboratory for analysis.
  • The test measures the level of cold agglutinins in the blood.
  • Results are used to diagnose Cold Agglutinin Disease.
  • It assess its impact on red blood cells.
  • The procedure is quick and minimally invasive.

 

Cold Agglutinins Test Result

Here is basic meaning of Cold Agglutinins Test.

  • Cold agglutinin test results are reported as a titer, such as 1:64 or 1:512.
  • A higher titer indicates a greater presence of cold agglutinins.
  • Elevated titers may suggest the presence of Cold Agglutinin Disease or related conditions.

 

Cold Agglutinins Test Normal Result

Here is the normal result of the Cold Agglutinins Test.

Test Normal Result
Cold Agglutinins Titer 1:64 or 1:512

 

Cold Agglutinins Test Interpretation

Here is the Interpretation of the Cold Agglutinins Test.

Test Result Interpretation
1:64 or lower Normal result, within the expected range.
1:128 to 1:512 Elevated titer, may indicate the presence of cold agglutinins.
1:1024 or higher High titer, often associated with more severe hemolytic anemia and symptoms.

A Cold Agglutinins Test measures cold agglutinin levels, with higher titers potentially indicating Cold Agglutinin Disease or related conditions.

 

Cold Agglutinins Test Positive Result

Here are the potential causes of positive Cold Agglutinins Test.

Possible Causes Effects
Cold Agglutinin Disease Hemolytic anemia, fatigue, cold-related symptoms.
Infections (e.g., Mycoplasma pneumoniae) Increased cold agglutinins, potential anemia.
Certain Cancers (e.g., lymphoma, leukemia) Elevated cold agglutinins, anemia in some cases.
Other Infections (e.g., HIV, influenza) Raised cold agglutinins, potential for anemia.
Parasitic Infections (e.g., malaria) Increased cold agglutinins, risk of anemia.
Bacterial Infections (e.g., syphilis) Elevated cold agglutinins, potential anemia.

A positive Cold Agglutinins Test can indicate various causes, including Cold Agglutinin Disease, infections, and certain cancers.

 

Cold Agglutinins Test Negative Result

Here are the potential causes of negative Cold Agglutinins Test.

Causes Effects
Absence of Cold Agglutinin Disease No associated hemolytic anemia or cold symptoms.
Lack of relevant infections or diseases No elevated cold agglutinins or related effects.
Normal antibody response Within the expected range of titer values.

A negative Cold Agglutinins Test suggests the absence of Cold Agglutinin Disease and related conditions, indicating a normal result.

 

Specimen Requirements For Cold Agglutinins Test

Here are the specimen requirements for the Cold Agglutinins Test.

Specimen

Serum

Volume

1 ml

Container

Red-top tube or gel-barrier tube

Collection

Transport blood to lab, incubate at 37°C for clotting; if no incubator, allow room temp clotting, then separate serum.

Storage

Refrigerate

Causes for Rejection

Refrigeration of the specimen before separating serum from cells

 

Cold Agglutinins Test is Safe?

  • The Cold Agglutinins Test is generally safe.
  • It involves a routine blood draw.
  • Minimal risk of bruising or soreness at the needle site.
  • Standard laboratory safety measures are followed.
  • Performed by trained healthcare professionals.

 

When Do You Get Cold Agglutinins Test Results? 

  • Cold Agglutinins Test results typically available in a few days.
  • Reporting time may vary by the laboratory.
  • Healthcare provider will communicate the results to the patient.

 

Cold Agglutinins Test Limitation

Here is the basic limitation of Cold Agglutinins Test.

  • May not identify all cases of Cold Agglutinin Disease.
  • Results can be influenced by various factors, including test methodology.
  • False negatives may occur, especially in early stages.
  • Test may not pinpoint the specific underlying cause of elevated cold agglutinins.
  • Diagnosis and treatment should consider clinical symptoms alongside test results.

 

Cold Agglutinins Test Risk Factors

Here are some of the risk factors of the Cold Agglutinins Test.

  • Cold Agglutinins Test is a low-risk blood test.
  • Minimal risk of discomfort or bruising at the blood draw site.
  • No significant general risk factors associated with the test.
  • Routine safety precautions are followed during the procedure.
  • Administered by trained healthcare professionals, reducing the risk of complications.

 

Doctor Recommendations After Cold Agglutinins Test Result

 Here are the Doctor's recommendations or consult a specialist after the Cold Agglutinins Test.

Test Result Doctor to Visit Reason
Positive Hematologist Diagnose and manage related conditions.
Negative Consulting physician Discuss overall health and symptoms.

 

Cold Agglutinins Test Price

Here are the estimated Cold Agglutinins Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

300-800

New Delhi

350-750

Bangalore

300-800

Hyderabad

350-750

Kolkata

300-800

Pune

350-750

Lucknow

300-800

Noida

350-750

Surat

350-750

Gurugram

300-800

Patna

350-750

Chennai

300-800

Jaipur

350-750

Ahmedabad

300-800

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, The Cold Agglutinins Test detects antibodies impacting red blood cells in cold temperatures. It helps diagnose Cold Agglutinin Disease and related conditions. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Cold agglutinin disease - Wikipedia [1].
  • Cold Agglutinins Disease - NIH [2].
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Cold Agglutinins Test FAQ

What is a Cold Agglutinins Test?

The Cold Agglutinins Test is a blood test that helps diagnose conditions related to the presence of cold agglutinins, antibodies that can cause red blood cells to clump together at lower temperatures. This test is crucial for identifying conditions like cold agglutinin disease.

How is the Cold Agglutinins Test performed?

To perform the test, a blood sample is taken from a vein in your arm. The sample is then exposed to different temperatures, and the reaction of your blood with cold temperatures is analyzed.

Why is the Cold Agglutinins Test done?

This test is done to diagnose and monitor conditions like autoimmune hemolytic anemia, Mycoplasma pneumonia infection, and other diseases that cause the production of cold agglutinins.

What is the cost of a Cold Agglutinins Test?

The cost of the test may vary depending on your location, healthcare facility, and insurance coverage. Check with your healthcare provider or your insurance company for information on pricing and potential financial assistance.

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