The Anti-Histone Antibodies Test is a blood test that detects antibodies against histones, and proteins associated with DNA in the cell nucleus. It helps in diagnosing autoimmune conditions like drug-induced lupus or certain types of arthritis.
Here are the basic details of the Anti-Histone Antibodies Test.
Test Name | Anti-Histone Antibodies Test |
---|---|
Also Known As | Histone Antibodies Test |
Type | Blood Test |
Purpose | Detect Autoimmune Disorders |
Sample Type | Blood Sample |
Preparation | None |
Fasting | Not Required |
Gender | All |
Age Group | All |
Normal Value | Negative (No Antibodies Detected) |
Reporting Time | Within 24 hours |
Cost | 1000-2000 INR* |
*Price range may vary as per location, lab type, and procedure of lab test.
The Anti-Histone Antibodies test measures the presence and concentration of antibodies against histones in a person's blood.
The purpose of the Anti-Histone Antibodies Test is to:
Here is the basic preparation for the Anti-Histone Antibodies Test.
Here is the basic Anti-Histone Antibodies Test Procedure.
Here is the basic reading of the Anti-Histone Antibodies Test results.
Anti-Histone Antibodies Positive Test Report
Anti-Histone Antibodies Negative Test Report
Here is the normal range of the Anti-Histone Antibodies Test
Value | Explanation of Results |
---|---|
<1.0 | Negative |
1.0-1.5 | Weak Positive |
1.6-2.5 | Moderate Positive |
>2.5 | Strong Positive |
Here is the Interpretation of the Anti-Histone Antibodies Test.
Test Result | Interpretation |
---|---|
Positive | Elevated antibodies |
Negative | Antibodies absent |
Here are the potential causes of Anti-Histone Antibodies Test Positive Results.
Potential Causes | Description |
---|---|
Drug-Induced Lupus | Some medications, such as hydralazine and procainamide, can lead to drug-induced lupus with positive anti-histone antibodies. |
Idiopathic or Autoimmune Disorders | Positive results may be associated with autoimmune diseases, such as systemic lupus erythematosus (SLE) or idiopathic cases. |
Inflammatory or Connective Tissue Diseases | Conditions like rheumatoid arthritis or mixed connective tissue disease may lead to positive results. |
Infections | Certain infections, like viral hepatitis, may trigger the production of anti-histone antibodies. |
Environmental or Occupational Exposure | Exposure to environmental toxins or occupational hazards can lead to positive anti-histone antibodies. |
Medications | Some medications used to treat conditions like cancer and autoimmune diseases can induce the production of anti-histone antibodies. |
Positive anti-histone antibody results typically warrant further investigation to determine the underlying cause and to guide treatment decisions. A healthcare professional should be consulted for a comprehensive evaluation.
Here are the potential causes of Anti-Histone Antibodies Test Negative Results.
Potential Causes | Description |
---|---|
Absence of Autoimmune Conditions | Negative results may suggest the absence of autoimmune diseases associated with anti-histone antibodies. |
No Drug-Induced Lupus | A lack of histone antibodies may indicate that drug-induced lupus is not present. |
No Infections | The absence of certain infections that can trigger anti-histone antibody production. |
No Environmental or Occupational Exposure | The individual may not have been exposed to relevant toxins or occupational hazards. |
Medication History | Negative results may be due to the absence of medications known to induce anti-histone antibodies. |
Healthy Immune System | A well-functioning immune system may not produce anti-histone antibodies in the absence of relevant triggers. |
Negative anti-histone antibody results are typically reassuring, but further clinical evaluation may be necessary if the suspicion of autoimmune or drug-induced conditions remains. Consulting a healthcare professional is essential for proper interpretation and diagnosis.
Here are the specimen requirements for the Anti-Histone Antibodies Test.
Specimen |
Serum |
|
Volume |
1 ml |
|
Container |
Red-top tube or gel-barrier tube |
|
Collection |
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. |
|
Storage |
Refrigerate or freeze. |
|
Sample Stability |
Temperature |
Period |
Room temperature |
14 days |
|
Refrigerated |
14 days |
|
Frozen |
14 days |
|
Causes for Rejection |
Hemolysis; icterus; lipemia; bacterial contamination. |
The Anti-Histone Antibodies Test is safe, involving a routine blood sample collection conducted by trained professionals.
Here is the basic limitation of Anti-Histone Antibodies Test.
Here are some of the risk factors of the Anti-Histone Antibodies Test.
Here are the Doctor's recommendations or consult a specialist after the Anti-Histone Antibodies Test.
Test Result | Doctor to Visit | Reason to See Doctor |
---|---|---|
Positive | Rheumatologist | Evaluate autoimmune or drug-induced conditions. |
Negative | General Practitioner | Confirm no histone antibodies presence. |
Here are the estimated Anti-Histone Antibodies Test Prices in India with different top cities:
City |
Price Range (INR)* |
1000-2000 |
|
1200-2000 |
|
1000-2000 |
|
1200-2000 |
|
1000-2000 |
|
1200-2000 |
|
1000-2000 |
|
1200-2000 |
|
1200-2000 |
|
1000-2000 |
|
1200-2000 |
|
1000-2000 |
|
1200-2000 |
|
1000-2000 |
*Anti-Histone Antibodies Test Prices are approximate and vary depending on a specific laboratory or healthcare facility.
Summary
Overall, Anti-Histone Antibodies Test is critical for diagnosing and managing autoimmune conditions affecting connective tissues. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.
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