Anti-Histone Antibodies Test For Lupus and Types of Arthritis

Anti-Histone Antibodies Test For Lupus and Types of Arthritis

The Anti-Histone Antibodies Test is a blood test that detects antibodies against histones, and proteins associated with DNA in the cell nucleus. It helps in diagnosing autoimmune conditions like drug-induced lupus or certain types of arthritis.

 

Anti-Histone Antibodies Test

Here are the basic details of the Anti-Histone Antibodies Test.

Test Name Anti-Histone Antibodies Test
Also Known As Histone Antibodies Test
Type Blood Test
Purpose Detect Autoimmune Disorders
Sample Type Blood Sample
Preparation None
Fasting Not Required
Gender All
Age Group All
Normal Value Negative (No Antibodies Detected)
Reporting Time Within 24 hours
Cost 1000-2000 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

 

Anti-Histone Antibodies Test Means

The Anti-Histone Antibodies test measures the presence and concentration of antibodies against histones in a person's blood.

  • Histones are proteins associated with DNA in the cell nucleus and play a role in gene regulation.
  • This test is crucial for diagnosing autoimmune diseases like systemic lupus erythematosus (SLE) and drug-induced lupus.
  • Results are reported as the presence or absence of these specific antibodies and their concentration, if present.
  • Abnormal results may indicate autoimmune disorders affecting the connective tissues.
  • The test aids in diagnosing and monitoring autoimmune conditions.

 

Anti-Histone Antibodies Test Purpose

The purpose of the Anti-Histone Antibodies Test is to:

  • Diagnose autoimmune diseases like systemic lupus erythematosus (SLE).
  • Detect the presence and concentration of anti-histone antibodies.
  • Monitor autoimmune disorders affecting connective tissues.
  • Assess treatment effectiveness and disease progression.
  • Aid in the management of autoimmune conditions.
  • Facilitate targeted medical interventions.

Anti-Histone Antibodies Test- Price, Normal Range, Result, Purpose, Procedure Meaning and Interpretation - Drlogy Test

 

Anti-Histone Antibodies Test Preparation

Here is the basic preparation for the Anti-Histone Antibodies Test.

 

Before Test

  • No specific dietary restrictions.
  • Inform the healthcare provider of any medications or medical conditions.
  • Understand the test's purpose and its relevance to autoimmune disease diagnosis.

 

During Test

  • No specific actions are required during the test.

 

After Test

  • Follow any post-test instructions given by the healthcare provider.
  • Discuss the results and their implications for autoimmune disease diagnosis and management.
  • Be prepared to follow up with additional tests or treatments as recommended.

 

Anti-Histone Antibodies Test Procedure

Here is the basic Anti-Histone Antibodies Test Procedure.

  • The Anti-Histone Antibodies Test involves collecting a blood sample from the patient, typically from a vein in the arm.
  • The collected blood is processed in the laboratory to isolate the serum.
  • The laboratory technician uses specific techniques, such as enzyme-linked immunosorbent assay (ELISA), to detect the presence and concentration of anti-histone antibodies.
  • Test results are reported as the presence or absence of these antibodies and their concentration if detected.
  • The procedure is crucial for diagnosing autoimmune diseases affecting connective tissues.
  • Accurate results assist in managing autoimmune conditions effectively.

 

Anti-Histone Antibodies Test Result

Here is the basic reading of the Anti-Histone Antibodies Test results.

  • Check the test report for the presence or absence of anti-histone antibodies.
  • A positive result indicates the presence of these antibodies.
  • The concentration is typically not provided in a binary result, but the presence suggests possible autoimmune conditions affecting connective tissues.
  • Discuss the results with a healthcare provider for further evaluation and management.

 

Anti-Histone Antibodies Test Positive Result Report Format

Anti Histone Antibodies Test Positive Result Report Format - Drlogy Test

Anti-Histone Antibodies Positive Test Report

Anti-Histone Antibodies Test Positive Result Report

 

Anti-Histone Antibodies Test Negative Result Report Format

Anti Histone Antibodies Test Negative Result Report Format - Drlogy Test

Anti-Histone Antibodies Negative Test Report

Anti-Histone Antibodies Test Negative Result Report

 

Anti-Histone Antibodies Test Normal Range

Here is the normal range of the Anti-Histone Antibodies Test

Value Explanation of Results
<1.0 Negative
1.0-1.5 Weak Positive
1.6-2.5 Moderate Positive
>2.5 Strong Positive

 

Anti-Histone Antibodies Test Interpretation

Here is the Interpretation of the Anti-Histone Antibodies Test.

Test Result Interpretation
Positive Elevated antibodies
Negative Antibodies absent

 

Anti-Histone Antibodies Test Positive Results

Here are the potential causes of Anti-Histone Antibodies Test Positive Results.

Potential Causes Description
Drug-Induced Lupus Some medications, such as hydralazine and procainamide, can lead to drug-induced lupus with positive anti-histone antibodies.
Idiopathic or Autoimmune Disorders Positive results may be associated with autoimmune diseases, such as systemic lupus erythematosus (SLE) or idiopathic cases.
Inflammatory or Connective Tissue Diseases Conditions like rheumatoid arthritis or mixed connective tissue disease may lead to positive results.
Infections Certain infections, like viral hepatitis, may trigger the production of anti-histone antibodies.
Environmental or Occupational Exposure Exposure to environmental toxins or occupational hazards can lead to positive anti-histone antibodies.
Medications Some medications used to treat conditions like cancer and autoimmune diseases can induce the production of anti-histone antibodies.

Positive anti-histone antibody results typically warrant further investigation to determine the underlying cause and to guide treatment decisions. A healthcare professional should be consulted for a comprehensive evaluation.

 

Anti-Histone Antibodies Test Negative Results

Here are the potential causes of Anti-Histone Antibodies Test Negative Results.

Potential Causes Description
Absence of Autoimmune Conditions Negative results may suggest the absence of autoimmune diseases associated with anti-histone antibodies.
No Drug-Induced Lupus A lack of histone antibodies may indicate that drug-induced lupus is not present.
No Infections The absence of certain infections that can trigger anti-histone antibody production.
No Environmental or Occupational Exposure The individual may not have been exposed to relevant toxins or occupational hazards.
Medication History Negative results may be due to the absence of medications known to induce anti-histone antibodies.
Healthy Immune System A well-functioning immune system may not produce anti-histone antibodies in the absence of relevant triggers.

Negative anti-histone antibody results are typically reassuring, but further clinical evaluation may be necessary if the suspicion of autoimmune or drug-induced conditions remains. Consulting a healthcare professional is essential for proper interpretation and diagnosis.

 

Specimen Requirements For Anti-Histone Antibodies Test

Here are the specimen requirements for the Anti-Histone Antibodies Test.

Specimen

Serum

Volume

1 ml

Container

Red-top tube or gel-barrier tube

Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Storage

Refrigerate or freeze.

Sample Stability

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Causes for Rejection

Hemolysis; icterus; lipemia; bacterial contamination.

 

Anti-Histone Antibodies Test is Safe?

The Anti-Histone Antibodies Test is safe, involving a routine blood sample collection conducted by trained professionals.

  • The test's risks are minimal, with potential side effects limited to mild discomfort or bruising at the blood draw site.
  • It is considered a safe diagnostic tool used for the detection of autoimmune conditions.

 

When Do You Get Anti-Histone Antibodies Test Results? 

  • Anti-Histone Antibodies Test results are typically available within 24 hours, depending on the laboratory's processing speed.
  • Patients can expect to receive their test results from their healthcare provider once the analysis is finished.

 

Anti-Histone Antibodies Test Limitation

Here is the basic limitation of Anti-Histone Antibodies Test.

  • The presence of anti-histone antibodies does not confirm a specific autoimmune disease.
  • Results may not capture fluctuations in antibody levels over time.
  • Limited to detecting anti-histone antibodies and may not identify other relevant autoantibodies.
  • Interpretation can be challenging due to variations in antibody profiles.
  • Positive results require clinical correlation for a definitive diagnosis.

 

Anti-Histone Antibodies Test Risk Factors

Here are some of the risk factors of the Anti-Histone Antibodies Test.

  • Risk factors may include autoimmune diseases like systemic lupus erythematosus (SLE).
  • Medications or medical conditions that can cause drug-induced lupus.
  • Previous exposure to drugs or environmental factors associated with lupus.
  • Demographic factors may influence antibody prevalence, such as age and gender.
  • Inaccurate results can occur if the test is not conducted correctly or interpreted in isolation.

 

Doctor Recommendations After Anti-Histone Antibodies Test Result

 Here are the Doctor's recommendations or consult a specialist after the Anti-Histone Antibodies Test.

Test Result Doctor to Visit Reason to See Doctor
Positive Rheumatologist Evaluate autoimmune or drug-induced conditions.
Negative General Practitioner Confirm no histone antibodies presence.

 

Anti-Histone Antibodies Test Price

Here are the estimated Anti-Histone Antibodies Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

1000-2000

New Delhi

1200-2000

Bangalore

1000-2000

Hyderabad

1200-2000

Kolkata

1000-2000

Pune

1200-2000

Lucknow

1000-2000

Noida

1200-2000

Surat

1200-2000

Gurugram

1000-2000

Patna

1200-2000

Chennai

1000-2000

Jaipur

1200-2000

Ahmedabad

1000-2000

*Anti-Histone Antibodies Test Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, Anti-Histone Antibodies Test is critical for diagnosing and managing autoimmune conditions affecting connective tissues. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Anti-Histone Antibodies - Wikipedia [1].
  • Anti-Histone Antibodies Test - Labcorp [2].

 

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Anti-Histone Antibodies Test FAQ

What does a positive histone antibodies test mean?

A positive histone antibodies test may indicate autoimmune or drug-induced lupus, where the immune system targets histone proteins in the cell nucleus.

What is the significance of anti-histone antibodies?

Anti-histone antibodies are associated with certain autoimmune conditions and drug-induced lupus. They target histone proteins and can help in diagnosis and disease management.

What is the cost of anti-histone antibody test?

The cost of an anti-histone antibody test varies by location and healthcare provider, typically ranging from $50 to $200 or more.

What makes histone positive?

Histone antibodies are considered positive when detected in a patient's blood, indicating an immune response against histone proteins, often in the context of autoimmune diseases.

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