Low Serum Calcium levels, known as hypocalcemia, can occur due to various factors. Common causes include vitamin D deficiency, hypoparathyroidism (underactive parathyroid glands), certain medications (such as bisphosphonates or antiepileptic drugs), kidney disease, malabsorption disorders, pancreatitis, and certain types of cancers. Additionally, low levels of albumin (a protein that binds to Calcium) can affect the measured Serum Calcium levels. Hypocalcemia can lead to symptoms like muscle cramps, numbness, tingling, and can have serious effects on the cardiovascular and nervous systems. It is important to identify and address the underlying cause of low Calcium levels for appropriate treatment.