Anti CCP Test For Joint Inflammation

Anti CCP Test For Joint Inflammation

The Anti CCP Test or Anti-Cyclic Citrullinated Peptide Test, is used to check for rheumatoid arthritis by detecting specific antibodies associated with joint inflammation. It helps diagnose and manage this autoimmune joint disease.


Anti CCP Test

Here are the basic details of the Anti CCP Test.

Also Known As Anti-Cyclic Citrullinated Peptide Test
Type Blood Test
Purpose Diagnosis of Rheumatoid Arthritis (RA)
Sample Type Serum
Preparation No
Fasting No
Gender Unisex
Age Group 18+
Normal Value <5 U/mL
Reporting Time 1-2 days
Cost 800-2000 INR*

*Price range may vary as per location, lab type, and procedure of lab test.


Anti CCP Test Means

ALP is primarily found in the liver, biliary tract epithelium, bone, intestinal mucosa, and placenta.

  • It functions in an alkaline environment (pH of 9 to 10).
  • Elevated ALP levels indicate liver or bone disorders.
  • It is used to differentiate between liver and bone diseases.
  • Isoenzymes (ALP1 and ALP2) help identify the source.
  • High ALP1 suggests liver disease, while high ALP2 indicates bone disease.
  • Elevated ALP2 with normal 5'-nucleotidase levels suggests bone as the source.
  • Recent meal ingestion can increase ALP levels.
  • Age, drugs, and certain substances can affect ALP levels.


Anti CCP Test Purpose

The purpose of the Anti CCP Test is to:

  • Diagnose rheumatoid arthritis.
  • Detect joint inflammation markers.
  • Evaluate autoimmune joint disease.
  • Guide treatment and management.
  • Monitor RA progression and response to therapy.

Anti CCP Test Price, Normal Range, Result, Purpose, Meaning and Interpretation - Drlogy Test


Anti CCP Test Preparation

Here is the basic preparation for the Anti CCP Test.


Before Test

  • No specific dietary or medication restrictions.
  • Inform your healthcare provider about any medications you're taking.


During Test

  • A blood sample is taken from a vein in your arm.


After Test

  • Apply pressure or a pressure dressing to the venipuncture site.
  • Assess the venipuncture site for bleeding.
  • Patients with liver dysfunction often have prolonged clotting times.


Anti CCP Test Procedure

Here is the basic Anti CCP Test Procedure.

  • Collect a venous blood sample in a tube.
  • Apply pressure or a pressure dressing to the venipuncture site.
  • Assess the venipuncture site for bleeding.
  • Monitor clotting times in patients with liver dysfunction.


Anti CCP Test Result

  • Anti-CCP test measures antibodies linked to rheumatoid arthritis.
  • Higher levels indicate a greater likelihood of RA.
  • Results help diagnose and manage the disease.


Anti CCP Test Report

Anti CCP Test Report Format Example Sample Template - Drlogy Lab Report

Anti CCP Test Report PDF


Anti CCP Test Positive Report

Anti Ccp Positive Test Report Format Example Sample Template - Drlogy Pathology Lab Report Format

Anti CCP Positive Test Report PDF Format

Anti CCP Test Positive Result Report PDF


Anti CCP Test Negative Report

Anti Ccp Negative Test Report Format Example Sample Template - Drlogy Pathology Lab Report Format

Anti CCP Negative Test Report PDF Format

Anti CCP Test Negative Result Report PDF


Anti CCP Test Normal Range

Here is the normal reference range for Anti CCP Test. It can vary slightly depending on the laboratory and measurement units used.

Anti CCP Level Normal Range
Adult <5 U/mL


Anti CCP Test Interpretation

Here is the Interpretation of the Anti CCP Test.

Anti CCP Level (U/mL) Interpretation
<5 Normal Condition
5-10 Borderline
>10 Elevated (Possible Rheumatoid Arthritis)


Anti CCP Test High Levels

Here are the Potential causes of high Anti CCP (Anti-Cyclic Citrullinated Peptide) levels.

Potential Causes Description
Rheumatoid Arthritis (RA) Commonly used to diagnose and monitor RA.
Other Autoimmune Diseases Elevated levels may be seen in other autoimmune disorders.
Joint Inflammation Presence of joint inflammation and damage.
Predictive of Severe RA Higher levels may indicate more severe RA.
Indicator of Disease Activity in RA Used to assess disease activity and treatment response in RA.


Anti CCP Test Low Levels

Here are the Potential causes of low Anti CCP (Anti-Cyclic Citrullinated Peptide) levels.

Potential Causes Description
Absence of Rheumatoid Arthritis (RA) Low levels are typically seen in individuals without RA.
Early Stage of Rheumatoid Arthritis Some individuals with RA may have low levels, especially in the early stages.
False Negative Test may not detect RA in some cases, leading to low levels.
Limited Disease Activity Low levels may indicate less active disease in established RA.
May Not Be a Reliable Indicator Alone Other RA tests and clinical evaluation are important for diagnosis.


Specimen Requirements For Anti CCP Test

Here are the specimen requirements for the Anti CCP Test.




1 ml


Red-top tube or gel-barrier tube


Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.


Refrigerate or freeze.

Sample Stability



Room temperature

7 day


14 days


60 days

Freeze/thaw cycles

Stable x1

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types.


Anti CCP Test is Safe?

Anti CCP tests are generally safe and involve a routine blood draw.

  • They are considered low-risk with minimal discomfort for patients.
  • Healthcare providers follow standard safety procedures to ensure patient well-being during the test.


When Do You Get Anti CCP Test Results? 

  • Anti CCP test results are typically available within a 1-2 days.
  • Patients can inquire about their anti CCP test results from their healthcare provider.


Anti CCP Test Limitation

Here is the basic limitation of Anti CCP Test.

  • Positive results don't confirm rheumatoid arthritis by themselves.
  • Some individuals with rheumatoid arthritis may have negative results.
  • The test is most useful when combined with other diagnostic assessments.


Anti CCP Test Risk Factors

Here are some of the risk factors of the Anti CCP Test.

  • Family history of autoimmune diseases.
  • Smoking may increase the risk.
  • Certain infections may trigger antibody production.


Doctor Recommendations After Anti CCP Test Result

 Here are the Doctor's recommendations or consult a specialist after the Anti CCP Test.

Anti CCP Test Result Doctor to Consult Possible Reasons
High Rheumatologist Rheumatoid arthritis or autoimmune conditions.
Normal Primary Care Physician Routine health assessment.
Low Rheumatologist Less common, autoimmune issues.


Anti CCP Test Price

Here are the estimated Anti CCP Test Prices in India with different top cities:


Price Range (INR)*



New Delhi


























*Prices are approximate and vary depending on a specific laboratory or healthcare facility.



Overall, Anti-CCP Test plays a vital role in diagnosing and managing rheumatoid arthritis, helping individuals achieve a better quality of life through early detection and treatment. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholars and medical students.



  • Anti–citrullinated protein antibody Anti CCP - Wikipedia [1].
  • Anti-cyclic citrullinated peptide antibody is a good indicator - NIH [2].


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Anti CCP Test FAQ

What is the anti-CCP test for?

The anti-CCP test is used to diagnose and assess the severity of rheumatoid arthritis (RA).

How do you treat high anti-CCP antibodies?

High anti-CCP antibodies are managed with RA treatments like DMARDs, biologics, and lifestyle modifications.

What if anti-CCP test is positive?

A positive anti-CCP test may indicate RA, and further evaluation by a rheumatologist is recommended.

What is anti-CCP normal range?

The normal range for anti-CCP is typically <20 units/mL, but it can vary depending on the lab and assay used.

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