CA 125 (Cancer Antigen 125) Test for Ovarian Cancer

CA 125 (Cancer Antigen 125) Test for Ovarian Cancer

CA 125 Test or Cancer Antigen 125 Test is a blood test that helps diagnose ovarian cancer. CA 125 Test measures the amount of a protein called CA 125 (cancer antigen 125) in a sample of your blood. CA 125 is a type of tumor marker. High levels of certain tumor markers in your blood may be a sign of cancer.

 

CA 125 Test

Here are the basic details for CA 125 Test.

Also Known As Ovarian Cancer marker, MUC16, Mucin 16, Cancer antigen 125
Type Blood Type
Purpose Diagnosis, Treatment Progress & Recurrence of Ovarian Cancer
Sample Type Serum
Preparation No Special Preparation Required
Fasting No
Gender Female
Age-Group Any
Normal Value 0 - 35 U/mL
Reporting Time 8 - 24 hours
Cost (INR) 750 - 1400 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

 

CA 125 Test Full Form

The Full Form of CA 125 Test is Cancer Antigen 125 Test.

 

CA 125 Test Means

The CA 125 test measures the levels of a protein called CA 125 in the blood.

  • CA 125 is primarily used as a tumor marker for ovarian cancer.
  • Elevated CA 125 levels may indicate the presence of ovarian cancer, although it can also be elevated in other conditions such as endometriosis, uterine fibroids, and pelvic inflammatory disease.
  • The CA 125 test is often used for monitoring ovarian cancer treatment, assessing response to therapy, and detecting cancer recurrence.
  • It is not a definitive diagnostic test for ovarian cancer and should be interpreted in conjunction with other clinical findings and imaging tests.
  • CA 125 levels can be normal in some individuals with early-stage ovarian cancer or elevated in those without cancer, limiting its specificity.
  • Serial CA 125 measurements over time are often more informative than a single measurement.
  • The test may also be used in certain cases of non-ovarian cancers, such as endometrial and fallopian tube cancers, to monitor disease progression and treatment response.

 

CA 125 Test Purpose

Here are the purposes of the CA 125 test.

  • The CA 125 test is used as a tumor marker for ovarian cancer.
  • It helps in the diagnosis of ovarian cancer, especially in combination with other diagnostic tests and imaging studies.
  • The test is used to monitor the progression of ovarian cancer and assess treatment response.
  • It aids in the detection of cancer recurrence in individuals previously diagnosed with ovarian cancer.
  • The CA 125 test may also be used in the evaluation of other gynecological conditions, such as endometriosis and uterine fibroids, although elevated levels can be found in non-cancerous conditions as well.
  • Serial CA 125 measurements are often used to track changes in levels over time, providing valuable information about disease progression or response to treatment.
  • The test may be utilized in certain cases of non-ovarian cancers, such as endometrial and fallopian tube cancers, to monitor treatment effectiveness.
  • Additionally, the CA 125 test can assist in determining the need for further diagnostic procedures or interventions.

 

CA 125 Test: Price, Normal Range, Result, Purpose

 

CA 125 Test Preparation

Here's a breakdown of the CA 125 test preparation covering the before, during, and after the test:

 

Before Test

  • Inform your healthcare provider about any medications, supplements, or herbal remedies you are currently taking.
  • Follow any specific instructions provided by your healthcare provider regarding fasting or dietary restrictions before the test.
  • Discuss any relevant medical conditions or recent surgeries with your healthcare provider.
  • Wear loose-fitting clothing that allows easy access to your arm for a blood draw.

 

During Test

  • A healthcare professional will draw a blood sample from a vein in your arm using a needle.
  • You may experience a brief prick or stinging sensation during the blood draw.
  • The process usually takes a few minutes to complete.

 

After Test

  • Apply pressure to the puncture site with a cotton ball or gauze to stop any bleeding.
  • If there is minor bruising or discomfort, you can apply a cold compress to the area.
  • Follow any post-test instructions given by your healthcare provider.
  • Resume your normal activities, including any medications or dietary routines unless otherwise instructed.
  • Your blood sample will be sent to a laboratory for analysis, and the results will be shared with you by your healthcare provider during a follow-up appointment.

 

CA 125 Test  Procedure

Here's a concise overview of the CA 125 test procedure.

  • No specific preparation is typically required for the CA 125 test.
  • A healthcare professional will draw a blood sample from a vein in your arm using a needle.
  • The blood sample will be collected in a tube or vial.
  • The sample will be sent to a laboratory for analysis to measure the levels of CA 125 protein.
  • Your healthcare provider will discuss the results with you and interpret them in the context of your medical history and symptoms.

 

CA 125 Test Result

  • CA 125 levels can vary among individuals, and the interpretation should always be done by a healthcare professional who considers the patient's specific circumstances.
  • It's important to consult with a doctor for personalized guidance and interpretation of CA 125 test results.

 

CA 125 Test Report

CA 125 Test Report - Drlogy Test

CA 125 Test Report PDF

 

CA 125 Test Normal Range

Here is the CA-125 test normal range values are given.

Test Name Normal Range
CA 125 Test Less than 35 Units/mL

 

CA 125 Test Interpretation

Here's an example of a CA 125 test interpretation:

CA 125 Level Interpretation
Below 35 U/mL Normal range, typically found in healthy individuals
35-100 U/mL Mildly elevated; may be seen in benign conditions
101-500 U/mL Moderately elevated; could indicate various factors
Above 500 U/mL Significantly elevated; further evaluation needed

 

CA 125 Test High Levels

Here are examples of CA 125 Test high levels causes.

CA 125 Test High Levels Causes
Ovarian cancer Endometriosis
Pancreatic cancer Pelvic inflammatory disease (PID)
Liver cancer Uterine fibroids
Breast cancer Peritoneal inflammation
Lung cancer Benign ovarian cysts
Endometrial cancer Rheumatoid arthritis
Colorectal cancer Cirrhosis
Ovarian cysts Kidney disease
Pelvic tumors Pancreatitis
Tubal pregnancy Inflammatory bowel disease (IBD)

 

CA 125 Test Low Levels

Here are examples of CA 125 Test low levels causes.

CA 125 Test Low Levels Causes
Early-stage ovarian cancer Normal or benign conditions
Endometriosis Pelvic inflammatory disease
Ovarian cysts Liver cirrhosis
Peritoneal tuberculosis First trimester of pregnancy
Ascites Hypothyroidism
Pleural effusion Meigs syndrome

 

Specimen Requirements For CA 125 Test

Here are the specimen requirements for the CA 125 Test.

Specimen Serum
Volume 0.8 ml
Container Red-top tube or gel-barrier tube

 

CA 125 Test is Safe?

The CA 125 test is generally considered safe and widely used in medical practice.

  • It involves a routine blood draw, which is a common and well-established procedure.
  • The risk of complications from the CA 125 test is minimal.
  • Some individuals may experience minor discomforts, such as a brief needle prick and possible bruising or soreness at the puncture site.
  • Serious adverse reactions or complications associated with the CA 125 test are extremely rare.

 

When Do You Get CA 125 Test Results?

The turnaround time for CA 125 test results can vary from 8 to 24 hours or depending on the laboratory where the test is conducted.

  • In many cases, you can expect to receive the results within a few days to a week.
  • However, it's important to note that the specific timeframe may depend on various factors, including the laboratory's workload and the location where the test is performed.

 

CA 125 Test Limitation

Here are some possible limitations of the CA 125 Test.

  • Limited specificity for detecting ovarian cancer.
  • Can be elevated in non-cancerous conditions.
  • Not suitable for early detection of ovarian cancer.
  • Levels may vary in different stages of ovarian cancer.
  • Not a definitive diagnostic test for ovarian cancer.

 

CA 125 Test Risk Factors

Here is the potential risk factor of the CA 125 Test.

  • Limited by false positives and false negatives.
  • Inaccuracy in premenopausal women and individuals with endometriosis.
  • May not detect early-stage or non-epithelial ovarian cancers.
  • Risk of misinterpretation and overdiagnosis.

 

Doctor Recommendations After CA 125 Test Result

Here are Doctor's recommendations or consult a specialist after CA 125 Test.

CA 125 Test Result Doctor to Visit Reason
High Gynecologic Oncologist Evaluation of potential ovarian cancer or other gynecologic malignancies
Normal General Physician Routine follow-up and general medical care
Low General Physician Assessment for potential non-malignant conditions or other underlying causes

 

CA 125 Test Price

Here are the estimated CA 125 Test Prices in India with top different cities:

City Price Range (INR)*
Mumbai 750 - 1400
New Delhi 800 - 1400
Bangalore 750 - 1400
Hyderabad 800 - 1400
Kolkata 750 - 1400
Pune 800 - 1400
Lucknow 750 - 1400
Noida 800 - 1400
Surat 750 - 1400
Gurugram 800 - 1400
Patna 750 - 1400
Chennai 800 - 1400
Jaipur 800 - 1400
Ahmedabad 750 - 1400

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, CA 125 Test is commonly used blood test to measure CA 125 levels, primarily for the evaluation of ovarian cancer, but interpretation should consider other clinical factors and it may also be elevated in non-cancerous conditions. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • CA 125 Test - Wikidoc [1].
  • What is CA 125? Questions About Ovarian Cancer Screening - OCRA [2].

 

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CA 125 Test FAQ

How fast can CA 125 rise?

The rate at which CA125 levels rise can vary depending on the underlying cause. In some cases, CA125 levels may rise slowly over time, while in other cases, the increase can be more rapid. CA125 levels can be influenced by factors such as the size and aggressiveness of the tumor, the stage of cancer, and individual variations. It's important to note that CA125 levels alone cannot provide a definitive diagnosis or predict the progression of cancer. Further diagnostic tests and evaluation by a healthcare professional are necessary to determine the cause of elevated CA125 levels and establish an accurate diagnosis.

What level of CA125 indicates cancer?

CA125 is a tumor marker primarily used for ovarian cancer, but it can also be elevated in other conditions. A normal CA125 level is typically less than 35 units per milliliter (U/mL). However, an elevated CA125 level does not necessarily mean cancer is present. In general, a level above 35 U/mL is considered higher than normal, but it is important to note that many non-cancerous conditions can cause CA125 levels to rise. Further diagnostic tests, such as imaging and biopsies, are needed to determine the cause of the elevated CA125 and confirm the presence of cancer.

What is CA 125 tested for?

CA 125 is a protein that is measured in a blood test. It is primarily used as a tumor marker for ovarian cancer. The CA 125 test is often performed in individuals who have symptoms suggestive of ovarian cancer, such as pelvic pain, bloating, or abnormal vaginal bleeding. It may also be used to monitor the response to treatment or detect the recurrence of ovarian cancer. However, it is important to note that CA 125 can also be elevated in non-cancerous conditions, such as endometriosis, pelvic inflammatory disease, or even during menstruation. Therefore, the CA 125 test is not a definitive diagnostic tool for ovarian cancer, but it can provide valuable information when used in conjunction with other diagnostic tests and clinical evaluation. A healthcare professional will interpret the CA 125 test results in the context of the individual's specific clinical situation.

What is CA 125 or CA 15-3?

CA 125 and CA 15-3 are both tumor markers used in cancer diagnosis and monitoring. CA 125 specifically refers to cancer antigen 125, which is primarily associated with ovarian cancer. Elevated CA 125 levels may also be found in other conditions, such as endometriosis or pelvic inflammatory disease. On the other hand, CA 15-3, or cancer antigen 15-3, is primarily associated with breast cancer. Similar to CA 125, CA 15-3 levels can also be elevated in non-cancerous conditions, making it important to consider other diagnostic tests and imaging studies for accurate assessment.

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