Urine Metanephrines To Measure Metanephrines in 24-hour Urine

The Urine Metanephrines Test checks for rare adrenal tumors that can cause high blood pressure, headaches, and other symptoms. It helps diagnose these tumors and assess treatment effectiveness. It's essential for early detection and management.

Urine Metanephrines Test

Here are the basic details of the Urine Metanephrines Test.

Also Known As	Metanephrine and Normetanephrine Test
Type	Urine test for hormone metabolites
Purpose	Detect rare adrenal tumors and assess treatment
Sample Type	Urine
Preparation	Follow healthcare provider's instructions
Fasting	Not required
Gender	Unisex
Age Group	All
Normal Value	24 to 96 mcg/24 hours
Reporting Time	24 hours
Cost	6000-9000 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

Urine Metanephrines Test Means

The Urine Metanephrines Test is a diagnostic tool for rare adrenal tumors, assessing hormone metabolites to detect or rule out pheochromocytomas and paragangliomas.

It involves a 24-hour urine collection, measuring metanephrine and normetanephrine levels.
It aids in early diagnosis, especially for those with hypertension, severe headaches, and other catecholamine-related symptoms.
The test doesn't usually require fasting and is suitable for all genders and age groups.
Normal values vary, and results are typically available within a few days.

Urine Metanephrines Test Purpose

The purpose of the Urine Metanephrines Test is to:

Urine Metanephrines Test identifies pheochromocytomas and paragangliomas.
Used post-treatment to check for tumor reappearance.
Helps diagnose the cause of persistent high blood pressure.
Useful for those with genetic predisposition to tumors.
Early detection prevents heart and kidney damage.

Urine Metanephrines Test_ Price, Normal Range, Result, Purpose, Meaning and Interpretation - Drlogy Test

Urine Metanephrines Test Preparation

Here is the basic preparation for the Urine Metanephrines Test.

Before Test

Follow healthcare provider's instructions.
Inform about medications and supplements.
Potential medication adjustments under guidance.
Avoid specific foods, stress, and vigorous exercise.

During Test

Collect all urine over 24 hours.
Store urine sample in the refrigerator.

After Test

Await results from the healthcare provider.
Discuss next steps as needed.

Urine Metanephrines Test Procedure

Here is the basic Urine Metanephrines Test Procedure.

Gather a 24-hour urine sample.
Keep the sample refrigerated during the collection period.
Laboratory measures metanephrine and normetanephrine levels.
Report available from the healthcare provider in a few days.

Urine Metanephrines Test Result

Normal levels suggest no tumor.
Elevated levels indicate possible tumor presence.
Recurrent elevation may suggest treatment ineffectiveness or tumor recurrence.

Urine Metanephrines Test Normal Range

Here is the normal range of the Urine Metanephrines Test.

Analyte	Normal Range (µg/24 hrs)
Metanephrine	Not established (0-3 months)
	25-117 (>3 months-5 yrs)
	11-139 (>5-10 yrs)
	51-275 (>10-14 yrs)
	40-189 (>14-17 yrs)
	74-297 (>17 yrs)
Normetanephrine	Not established (0-3 months)
	54-249 (>3 months-5 yrs)
	31-398 (>5-10 yrs)
	67-503 (>10-14 yrs)
	69-531 (>14-17 yrs)
	73-808 (>17 yrs)

Urine Metanephrines Test Interpretation

Here is the Interpretation of the Urine Metanephrines Test.

Test Results	Interpretation
Normal	Unlikely presence of catecholamine-producing tumors.
Elevated	Suggests possible tumor presence.
Persistent	May indicate ineffective treatment or tumor recurrence.

Urine Metanephrines Test High Levels

Here are some possible causes of high Urine Metanephrines levels:

Possible Causes	Effects
Pheochromocytomas and paragangliomas	Symptoms like hypertension, headaches, sweating.
Certain medications	May interfere with test results.
Stressful situations	Temporary elevation of metanephrines.
Smoking and specific foods	Can influence test results.

Urine Metanephrines Test Low Levels

Here are some possible causes of low Urine Metanephrines levels:

Possible Causes	Effects
Absence of catecholamine-producing tumors	Suggests no tumor presence.
Appropriate medications or treatment	May reduce catecholamine production.
Normal response to non-stressful conditions	Metanephrines remain within normal range.

Specimen Requirements For Urine Metanephrines Test

Here are the specimen requirements for the Urine Metanephrines Test.

Specimen	Urine (24-hour)
Volume	10 mL aliquot
Container	Plastic urine container with no preservative or 6N HCl
Collection	Void at 8 AM, discard. Collect 24-hour urine. Label, measure volume, mix, send. Use HCl if needed.
Storage	Room temperature
Sample Stability	Temperature	Period
	Room temperature	14 days
	Refrigerated	14 days
	Frozen	14 days

Urine Metanephrines Test is Safe?

Urine Metanephrines Test is generally safe and non-invasive, involving urine collection.
It poses minimal risk of complications or side effects.
No radiation or harmful substances are used during the test.
Consult with your healthcare provider for specific safety concerns.
Follow provided instructions and discuss any allergies or sensitivities.

When Do You Get Urine Metanephrines Test Results?

Urine Metanephrines Test results are typically available within a few days.
The exact turnaround time may vary depending on the laboratory and healthcare provider.
Your provider will inform you when the results are ready for review.
Be prepared to discuss the findings and any necessary follow-up actions.
Results should be interpreted by a qualified healthcare professional.

Urine Metanephrines Test Limitation

Here is the basic limitation of Urine Metanephrines Test.

Results may be affected by medications, diet, stress, and smoking.
The test may occasionally yield elevated levels without tumor presence.
Fluctuating hormone levels during the day may impact accuracy.
It cannot determine tumor size, location, or malignancy.
Imaging studies are often needed for tumor localization and evaluation.

Urine Metanephrines Test Risk Factors

Here are some of the risk factors of the Urine Metanephrines Test.

Family history of pheochromocytomas or paragangliomas.
Certain genetic syndromes, like MEN-1 and MEN-2.
Age and gender (more common in certain age groups and genders).
Personal history of these tumors or related conditions.
Use of medications that may interfere with test results.

Doctor Recommendations After Urine Metanephrines Test Result

Here are the Doctor's recommendations or consult a specialist after the Urine Metanephrines Test.

Test Result	Doctor to Visit	Reason
High	Endocrinologist	Discuss tumor evaluation.
Normal	General Physician	Routine test follow-up.
Low	General Physician	Discuss findings as needed.

Urine Metanephrines Test Price

Here are the estimated Urine Metanephrines Test Prices in India with different top cities:

City	Price Range (INR)*
Mumbai	6000-9000
New Delhi	6500-8000
Bangalore	6000-9000
Hyderabad	6500-8000
Kolkata	6000-9000
Pune	6500-8000
Lucknow	6000-9000
Noida	6500-8000
Surat	6500-8000
Gurugram	6000-9000
Patna	6500-8000
Chennai	6000-9000
Jaipur	6500-8000
Ahmedabad	6000-9000

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

Summary

Overall, The Urine Metanephrines Test is crucial for detecting rare adrenal tumors. Learn about the procedure, results, and its significance. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholars and medical students.

Reference

Metanephrines - Wikipedia [1].
The role of urinary fractionated metanephrines in the ... - NCBI [2].

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Urine Metanephrines FAQ

What are urine metanephrines?

Urine metanephrines are a group of chemical compounds that can be detected in a urine sample. They are breakdown products of catecholamines, which are hormones released by the adrenal glands in response to stress. The main urine metanephrines of interest are metanephrine and normetanephrine. Measuring these compounds in urine is a valuable diagnostic tool for assessing adrenal function and detecting certain medical conditions, especially those related to the adrenal medulla, such as pheochromocytoma.

Why are urine metanephrines measured?

Urine metanephrines are measured to evaluate adrenal gland function and to diagnose or rule out conditions like pheochromocytoma. Pheochromocytoma is a rare tumor that can cause excessive release of catecholamines, leading to high blood pressure, rapid heart rate, and other symptoms. Elevated levels of metanephrines in the urine may indicate the presence of this tumor. Additionally, urine metanephrine testing can help monitor the effectiveness of treatment for pheochromocytoma.

How is a urine metanephrines test performed?

The test involves collecting a urine sample over a 24-hour period. The patient typically begins by discarding the first morning void and then collecting all urine for the next 24 hours. The urine is stored in a special container to prevent breakdown of metanephrines. After collection, the sample is sent to a laboratory for analysis. It's crucial to follow the specific instructions provided by the healthcare provider to ensure accurate results.

What does it mean if urine metanephrines are elevated?

Elevated urine metanephrine levels may suggest the presence of a pheochromocytoma or other conditions that lead to excessive catecholamine production. Further diagnostic tests, such as imaging studies and blood tests, may be necessary to confirm the diagnosis and locate the tumor. Elevated levels can also occur due to certain medications and dietary factors, so it's important to consider these aspects during the evaluation.