Thrombin Time Test For Plasma Clotting Time Measurement

Thrombin Time Test For Plasma Clotting Time Measurement

The Thrombin Time Test is a medical test that helps evaluate how well our blood can clot. It's used to check for bleeding or clotting problems. Doctors use this test to understand what might be causing someone's unusual bleeding or clotting issues.

 

Thrombin Time Test

Here are the basic details of the Thrombin Time Test.

Also Known As TT (Thrombin Time)
Type Blood test
Purpose Evaluate blood clotting
Sample Type Plasma
Preparation No
Fasting Not required
Gender Unisex
Age Group All
Normal Value 14-16 sec
Reporting Time A few days
Cost 200-1000 INR*

*Thrombin Time Test Price range may vary as per location, lab type, and procedure of lab test.

 

Thrombin Time Test Means

Thrombin Time Test is a blood test that measures how long it takes for a blood clot to form when thrombin is added, assessing fibrinogen's clotting function.

  • It helps diagnose bleeding disorders and evaluate the effectiveness of clotting factors.
  • A prolonged Thrombin Time suggests potential issues with fibrinogen or the presence of anticoagulants like heparin.
  • This test is useful in identifying the causes of abnormal bleeding or clotting episodes.
  • Thrombin Time Test is a valuable tool for understanding and managing hemostatic disorders.

 

Thrombin Time Test Purpose

The purpose of the Thrombin Time Test is to:

  • Thrombin Time Test determines how long it takes for blood to clot, assessing fibrinogen's functionality.
  • It's used to diagnose bleeding disorders and monitor clotting factor efficiency.
  • Helps identify potential issues with fibrinogen or the presence of anticoagulants.
  • Valuable in understanding the causes of bleeding or clotting abnormalities.
  • Essential in managing and treating hemostatic conditions.

Thrombin  Time Test_ Price, Normal Range, Result, Purpose, Procedure Meaning and Interpretation - Drlogy Test

 

Thrombin Time Test Preparation

Here is the basic preparation for the Thrombin Time Test.

 

Before Test

  • No special dietary or fasting requirements are needed before the test.
  • Inform your healthcare provider about any medications or supplements you are taking.
  • Wear clothing with easy access to your arm for the blood draw.

 

During Test

  • A healthcare professional will draw a blood sample from a vein in your arm.
  • You may feel a brief, mild discomfort during the blood draw.
  • Stay relaxed and follow any instructions provided by the phlebotomist.

 

After Test

  • You can resume your normal activities immediately.
  • It's essential to follow up with your healthcare provider to discuss your test results.
  • No specific post-test care or restrictions are typically necessary.

 

Thrombin Time Test Procedure

Here is the basic Thrombin Time Test Procedure.

  • Blood sample collection from a vein in the arm.
  • The collected blood is mixed with thrombin.
  • Timing the formation of a fibrin clot to assess clotting function.
  • The time taken for clot formation is recorded.
  • Results are analyzed by healthcare professionals to diagnose clotting disorders.

 

Thrombin Time Test Result

  • Normal Range: A typical Thrombin Time falls within the range of 12-14 seconds.
  • Prolonged Time: If the result is significantly longer, it may indicate issues with fibrinogen or the presence of anticoagulants.
  • Abnormalities: Healthcare providers interpret results in the context of medical history and other tests to diagnose bleeding or clotting disorders.

 

Thrombin Time Test Normal Range

Here is the normal range of the Thrombin Time Test.

Test Normal Range
Thrombin Time Test 14-16 seconds

 

Thrombin Time Test Interpretation

Here is the Interpretation of the Thrombin Time Test.

Thrombin Time Result Interpretation
Shortened Uncommon; may indicate hypercoagulability or technical issues.
Within Normal Range Typically 14-16 seconds; considered normal.
Prolonged May suggest fibrinogen issues or heparin contamination.
Abnormally Prolonged Indicates possible bleeding disorders or underlying health conditions.

 

Thrombin Time Test High Levels

Here are potential causes of high levels of Thrombin Time Test.

Possible Causes Effects
Fibrinogen deficiency or dysfunction Impaired blood clotting ability.
Heparin contamination of the sample Inaccurate clotting time results.
Liver disease or dysfunction Altered production of clotting factors.
Bleeding disorders Increased risk of abnormal bleeding.

 

Thrombin Time Test Low Levels

Here are potential causes of low levels of Thrombin Time Test.

Possible Causes Effects
Hypercoagulability or clotting disorders Increased risk of abnormal blood clots.
Technical issues in the test Erroneously shortened clotting time.
Not a common result Unusual, requires further investigation.

Low Thrombin Time may result from clotting disorders, technical errors, or uncommon findings, potentially increasing the risk of abnormal blood clot formation.

 

Specimen Requirements For Thrombin Time Test

Here are the specimen requirements for the Thrombin Time Test.

Specimen

Plasma

Volume

1 ml

Container

Blue-top (sodium citrate) tube

Collection

Citrated plasma samples should be collected by double centrifugation. Please submit separate frozen specimens for each test requested.

Storage

Freeze

Sample Stability

Temperature

Period

Room temperature

4 hours

Refrigerated

8 hours

Frozen

13 months

Freeze/thaw cycles

Stable x5

Causes for Rejection

Severe hemolysis; improper labeling; clotted specimen; specimen diluted with IV fluids; samples thawed in transit

 

Thrombin Time Test is Safe?

  • Thrombin Time Test is generally safe.
  • It's a routine blood test with minimal risks.
  • Risks are typical for any blood draw, like mild discomfort or bruising.
  • Performed by trained professionals, ensuring safety.

 

When Do You Get Thrombin Time Test Results? 

  • Thrombin Time Test results are typically available within a day or two.
  • The exact reporting time may vary depending on the laboratory and healthcare facility.
  • Your healthcare provider will inform you when the results are ready for review.

 

Thrombin Time Test Limitation

Here is the basic limitation of Thrombin Time Test.

  • Thrombin Time Test has limitations as it primarily assesses fibrinogen's function and may not reflect overall coagulation status.
  • It doesn't provide a comprehensive view of the entire coagulation cascade.
  • The test may not detect all bleeding or clotting disorders.
  • Factors like technical errors and variations in reagents can affect results.
  • Interpretation should consider the full clinical context and may require additional tests for a complete assessment.

 

Thrombin Time Test Risk Factors

Here are some of the risk factors of the Thrombin Time Test.

  • Thrombin Time Test itself has minimal risk factors as it is a routine blood test.
  • The standard risks are associated with blood sample collection, such as minor discomfort or bruising at the puncture site.
  • No major health risks are directly associated with the test.
  • Individuals with bleeding disorders may be at a higher risk of bleeding during sample collection.
  • Always inform the healthcare provider of any pre-existing medical conditions or medications that may affect the test or pose additional risks.

 

Doctor Recommendations After Thrombin Time Test Result

 Here are the Doctor's recommendations or consult a specialist after the Thrombin Time Test.

Thrombin Time Result Doctor to Visit Reason to Go
High Hematologist Abnormal blood clotting.
Normal No specific doctor -
Low Hematologist Risk of abnormal clot formation.

 

Thrombin Time Test Price

Here are the estimated Thrombin Time Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

200-1000

New Delhi

500-1000

Bangalore

200-1000

Hyderabad

300-1000

Kolkata

200-1000

Pune

300-1000

Lucknow

200-1000

Noida

300-1000

Surat

300-1000

Gurugram

200-1000

Patna

300-1000

Chennai

200-1000

Jaipur

300-1000

Ahmedabad

200-1000

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, Thrombin Time Test evaluates blood clotting function. High levels suggest issues with fibrinogen or contamination, while low levels may indicate clotting disorders, potentially necessitating further assessment. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Thrombin Time - Wikipedia [1].
  • Coagulation Tests - Clinical Methods - NCBI Bookshelf [2].
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Thrombin Time Test FAQ

What is a Thrombin Time Test?

The Thrombin Time Test is a medical diagnostic test that measures the time it takes for a patient's blood to clot in response to the enzyme thrombin. It is primarily used to assess the functionality of the final step in the blood clotting process, known as the fibrinogen-to-fibrin conversion. This test helps healthcare professionals identify bleeding disorders or clotting abnormalities.

How is the Thrombin Time Test performed?

To perform a Thrombin Time Test, a blood sample is collected from the patient. Thrombin, a clotting factor, is then added to the blood sample. The time it takes for the blood to form a stable clot is measured. This time is compared to established reference ranges to determine if the patient's clotting time falls within the normal range or if there is an abnormality in their blood's ability to clot.

What is the purpose of the Thrombin Time Test?

The Thrombin Time Test serves multiple purposes. It helps diagnose or monitor various conditions, including assessing the presence of clotting disorders, monitoring anticoagulant therapy effectiveness (like heparin therapy), and evaluating liver function. It can also be used before surgeries to ensure the patient's blood clotting ability is within a safe range.

How long does it take to receive Thrombin Time Test results?

Thrombin Time Test results are typically available within a day or two after the blood sample is collected. The time may vary depending on the laboratory's workload and testing protocols. It's best to consult with your healthcare provider regarding the specific timeline for receiving your test results.

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