Procalcitonin Test  To Detect Sepsis & Severe Bacterial Infections

Procalcitonin Test To Detect Sepsis & Severe Bacterial Infections

The Procalcitonin Test is a blood test that helps doctors identify serious bacterial infections, like sepsis, and guides them in deciding when to use antibiotics. When bacterial infections occurs that response to Procalcitonin (PCT) - a biomarker that is released in our body.

Procalcitonin Test

Here are the basic details of the Procalcitonin Test.

Also Known As PCT Test
Type Blood Test
Purpose Detects bacterial infections, guides antibiotic treatment decisions
Sample Type Blood
Preparation No
Fasting No
Gender Unisex
Age Group All
Normal Value > 0.1 ng/ml
Reporting Time within an hour
Cost 700-2800 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

 

Procalcitonin Test Means

The Procalcitonin Test is a diagnostic blood test used in healthcare.

  • It measures procalcitonin levels in the blood to detect bacterial infections and guide antibiotic treatment.
  • It helps assess the risk of severe infections like sepsis.
  • Procalcitonin Test results inform clinical decisions for critically ill patients.
  • Elevated levels may indicate systemic bacterial infections.

 

Procalcitonin Test Purpose

The purpose of the Procalcitonin Test is to:

  • Procalcitonin Test aids in detecting bacterial infections in critically ill patients.
  • It guides antibiotic treatment decisions for more effective care.
  • Assess risk of severe infections, like sepsis, through this test.
  • Procalcitonin levels help differentiate between bacterial and non-bacterial causes.
  • Monitoring procalcitonin levels can track the effectiveness of antibiotic therapy.

Procalcitonin Test_ Price, Normal Range, Result, Purpose, Meaning and Interpretation - Drlogy Test

 

Procalcitonin Test Preparation

Here is the basic preparation for the Procalcitonin Test.

 

Before Test

  • No special preparation is needed.
  • Inform the healthcare provider about any medications or allergies.
  • Ensure you're well-hydrated to facilitate blood draw.

 

During Test

  • A blood sample is drawn from a vein in your arm.
  • You may feel a brief needle prick during the blood draw.
  • The procedure is usually quick and relatively painless.

 

After Test

  • There are no specific post-test instructions.
  • You can resume normal activities immediately.
  • Your healthcare provider will discuss the results and any necessary actions.

 

Procalcitonin Test Procedure

Here is the basic Procalcitonin Test Procedure.

  • The patient's arm is cleaned with an antiseptic.
  • A healthcare professional inserts a needle into a vein to draw blood.
  • The blood sample is collected in a special tube.
  • The tube is sent to a laboratory for analysis.
  • Procalcitonin levels are measured using specific assays and equipment.
  • Results are typically available within a few hours to a day.
  • Healthcare providers interpret the results to aid diagnosis and treatment decisions.

 

Procalcitonin Test Result

  • Normal Range: Procalcitonin levels between 0 and 0.05 ng/L are considered normal.
  • Low Risk: Levels below 0.5 ng/L suggest a low risk of sepsis.
  • High Risk: Levels above 2 ng/L indicate a moderate to high risk of sepsis, with 10 ng/L or higher indicating severe sepsis.

 

Procalcitonin Test Normal Range

Here is the normal range of the Procalcitonin Test.

Procalcitonin Test Normal Range
Procalcitonin Level Less than 0.05 ng/mL

 

Procalcitonin Test Interpretation

Here is the Interpretation of the Procalcitonin Test.

Procalcitonin Level (UG/L) Interpretation
Less than 0.5 Systemic infection (sepsis) is not likely; possibility of local bacterial infection.
0.5 - 2 Sepsis is possible, but other infectious conditions may not be ruled out.
Greater than or equal to 10 High likelihood of severe sepsis or septic shock.

The Procalcitonin Test measures levels of procalcitonin in the blood to detect bacterial infections and assess the risk of sepsis.

 

Procalcitonin Test High Levels

Here are some possible causes of high Procalcitonin levels:

Possible Causes Interpretation
Severe bacterial infections (e.g., sepsis) High procalcitonin levels suggest a serious infection.
Meningitis, other serious bacterial illnesses Elevated levels may indicate a need for urgent treatment.
Severe sepsis or septic shock Urgent medical attention is likely necessary.
Medullary thyroid cancer High procalcitonin levels are not typically related to this condition.

High procalcitonin levels typically indicate severe bacterial infections, including sepsis, or serious bacterial illnesses requiring urgent medical attention.

 

Procalcitonin Test Low Levels

Here are some possible causes of low Procalcitonin levels:

Possible Causes Interpretation
Viral infections Low procalcitonin levels suggest a non-bacterial cause of illness.
Non-infectious conditions (e.g., trauma) The symptoms are likely due to factors other than bacterial infections.
Early-stage bacterial infections In some cases, bacterial infections may not have fully developed.

Low procalcitonin levels indicate non-bacterial causes, such as viral infections or non-infectious conditions, and may suggest early-stage bacterial infections.

 

Specimen Requirements For Procalcitonin Test

Here are the specimen requirements for the Procalcitonin Test.

Specimen

Serum

Volume

2 ml

Container

Red-top tube or gel-barrier tube

Storage

Refrigerate or freeze.

Sample Stability

Temperature

Period

Room temperature

14 day

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination; plasma specimen

 

Procalcitonin Test is Safe?

The Procalcitonin Test is generally safe.

  • It involves a simple blood draw, which carries minimal risk.
  • It's a routine diagnostic test performed in clinical settings.
  • Complications are rare but can include bruising or infection at the puncture site.
  • The benefits of early infection detection usually outweigh any minimal risks.

 

When Do You Get Procalcitonin Test Results? 

  • Procalcitonin test results are typically available within a few hours to a day.
  • Rapid turnaround is crucial in clinical settings for timely decisions.
  • The specific reporting time may vary depending on the laboratory and location.

 

Procalcitonin Test Limitation

Here is the basic limitation of Procalcitonin Test.

  • Not a stand-alone diagnosis.
  • Levels can be influenced by non-infectious factors.
  • Interpretation requires clinical context.
  • Reference ranges may vary.
  • Limited specificity for certain infections.

 

Procalcitonin Test Risk Factors

Here are some of the risk factors of the Procalcitonin Test.

  • No direct risk factors associated with the Procalcitonin Test.
  • Risk factors for conditions it helps diagnose include bacterial infections, recent surgery, chronic illness, and invasive medical devices.
  • These factors can increase the likelihood of sepsis or severe bacterial infections that prompt the test.
  • The test itself does not introduce additional risks to the patient.
  • Interpretation and clinical decisions should consider patient-specific risk factors.

 

Doctor Recommendations After Procalcitonin Test Result

 Here are the Doctor's recommendations or consult a specialist after the Procalcitonin Test.

Procalcitonin Test Result Doctor to Consult Reason
High Infectious Disease Specialist Possible severe bacterial infection or sepsis.
Normal Primary Care Physician Investigate non-bacterial causes of symptoms.
Low Primary Care Physician Assess early-stage bacterial infection.

Consult an Infectious Disease Specialist for high Procalcitonin results, your Primary Care Physician for normal results, and to assess early-stage bacterial infection with low results.

 

Procalcitonin Test Price

Here are the estimated Procalcitonin Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

700-2800

New Delhi

700-3000

Bangalore

700-2800

Hyderabad

700-3000

Kolkata

700-2800

Pune

700-3000

Lucknow

700-2800

Noida

700-3000

Surat

700-3000

Gurugram

700-2800

Patna

700-3000

Chennai

700-2800

Jaipur

700-3000

Ahmedabad

700-2800

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, The Procalcitonin Test aids in diagnosing bacterial infections and sepsis, guiding treatment decisions, with results indicating infection severity. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Procalcitonin - Wikipedia [1].
  • Procalcitonin Test - NIH [2].

 

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Procalcitonin Test FAQ

What does it mean if procalcitonin is high?

High procalcitonin levels often indicate a severe bacterial infection, especially in the bloodstream. Elevated levels can signal systemic inflammation, guiding clinicians to assess and manage bacterial infections.

What is the function of the procalcitonin?

Procalcitonin is a precursor to the hormone calcitonin. Its main function is to increase during bacterial infections and sepsis, serving as a biomarker for systemic inflammation. It helps clinicians differentiate between bacterial and viral infections.

What is procalcitonin test for TB?

The procalcitonin test is not specifically designed for tuberculosis (TB). TB is primarily diagnosed through tests like the tuberculin skin test, interferon-gamma release assays (IGRAs), and chest X-rays. Procalcitonin is more useful in identifying bacterial infections.

Is procalcitonin a good marker for infection?

Procalcitonin is a valuable marker for bacterial infections, aiding in distinguishing them from viral infections. Elevated levels prompt clinicians to investigate potential bacterial involvement. However, it is not specific to TB and should be used in conjunction with other diagnostic methods.

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