Immunoreactive Trypsinogen (IRT) Test For Cystic Fibrosis in Newborns

The Immunoreactive Trypsinogen (IRT) test is a medical exam used to screen for cystic fibrosis in newborns. It measures the levels of a specific enzyme in a blood sample to detect early signs of the disease.

IRT Test

Here are the basic details of the IRT Test.

*IRT Test Price range may vary as per location, lab type, and procedure of lab test.

IRT Test Means

The Immunoreactive Trypsinogen (IRT) test is a medical examination test.

• It's primarily used to screen for cystic fibrosis in newborns.
• This test measures the levels of a specific enzyme in the blood.
• Elevated IRT levels may indicate a risk of cystic fibrosis.
• Early detection is crucial for managing this genetic condition.
• The IRT test is an essential part of newborn screening programs.

IRT Test Purpose

The purpose of the IRT Test is to:

• Screen newborns for cystic fibrosis.
• Detect early signs of the disease.
• Enable timely intervention and management.
• Part of routine newborn screening.
• Improves health outcomes for affected infants.

IRT Test Preparation

Here is the basic preparation for the IRT Test.

Before Test

• No specific dietary or fluid restrictions are typically required.
• Ensure that the healthcare provider is aware of any medications or supplements your newborn is taking.

During Test

• A small blood sample is collected from the newborn, often from the heel.
• Comfort measures for the baby, like cuddling or feeding, may help soothe them.

After Test

• After the test, there are usually no specific post-test care instructions.
• Your healthcare provider will interpret the results and discuss any necessary follow-up actions.

IRT Test Procedure

Here is the basic IRT Test Procedure.

• The Immunoreactive Trypsinogen (IRT) test is commonly part of routine newborn screening.
• It involves collecting a small blood sample from the newborn's heel or another appropriate location.
• The healthcare provider uses a lancet to puncture the skin and obtain a few drops of blood.
• The blood sample is typically collected on filter paper.
• The sample is sent to a laboratory for analysis.
• Results are then interpreted to determine if further testing or follow-up is needed based on the IRT levels.
• This test is designed to screen for cystic fibrosis in newborns.

IRT Test Result

IRT (Immunoreactive Trypsinogen) test results are typically reported as a numerical value.

• The cutoff value for a "normal" or "abnormal" result can vary by the laboratory and the specific assay used.
• Elevated IRT levels may suggest a higher risk of cystic fibrosis in newborns.
• A result above the cutoff value often prompts further testing, like a sweat chloride test, to confirm the diagnosis.
• The interpretation of IRT results is typically done by healthcare professionals experienced in newborn screening.
• Parents will be informed of the results and any necessary follow-up or confirmatory testing steps if the initial result is elevated.

IRT Test Normal Range

Here is the normal range of the IRT Test

IRT Test Interpretation

Here is the Interpretation of the IRT Test.

IRT Test High Levels

Here are the potential causes of high IRT Levels.

IRT Test Low Levels

Here are the potential causes of low IRT Levels.

Specimen Requirements For IRT Test

Here are the specimen requirements for the IRT Test.

IRT Test is Safe?

The IRT test, performed on newborns, is generally safe and part of routine newborn screening.

• It involves a small blood sample, which may cause minimal discomfort but is well-tolerated by infants.
• The benefits of early cystic fibrosis detection outweigh the minimal risks associated with the test.

When Do You Get IRT Test Results? 

• IRT test results are usually reported shortly after the test is conducted, typically within a few days.
• Fast reporting is crucial for timely intervention in newborns.

IRT Test Limitation

Here is the basic limitation of the IRT Test.

• False positives: Elevated IRT levels can be caused by factors other than cystic fibrosis, leading to false positives.
• Limited specificity: IRT is a screening test, and further testing is often required to confirm a diagnosis.
• Doesn't identify specific mutations: It doesn't provide information about the specific cystic fibrosis gene mutations.
• Timing is critical: IRT levels can vary with time, and early detection is essential for accurate results.
• Regional variations: Cutoff values and interpretation may differ by region and screening program.

IRT Test Risk Factors

Here are some of the risk factors of the IRT Test.

• False positives due to non-cystic fibrosis factors.
• Regional variations in screening programs.
• Timing critical for accurate results.
• Limited specificity necessitates further testing.
• Confounding factors can affect IRT levels.

Doctor Recommendations After IRT Test Result

 Here are the Doctor's recommendations or consult a specialist after the IRT Test.

IRT Test Price

Here are the estimated IRT Test Prices in India with different top cities:

*IRT Test Price are approximate and vary depending on a specific laboratory or healthcare facility.

Summary

Overall, IRT Test as part of newborn screening, plays a vital role in early cystic fibrosis detection, ultimately improving health outcomes for affected infants. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

Reference

• Immunoreactive Trypsinogen (IRT)- Wikipedia [1].
• Cystic Fibrosis Newborn Screening: Distribution of Blood Immunoreactive Trypsinogen Concentrations in Hypertrypsinemic Neonates - NIH [2].