First Trimester Screening Test For Early Pregnancy Stage

First Trimester Screening Test For Early Pregnancy Stage

The First Trimester Screening Test is a prenatal evaluation performed during early pregnancy to assess the risk of chromosomal abnormalities, such as Down syndrome, in the developing fetus. It typically involves a combination of a maternal blood test and an ultrasound to provide important information to expectant parents and healthcare providers.

 

First Trimester Screening Test

Here are the basic details of the First Trimester Screening Test.

Also Known As First Trimester Screen
Type Blood test and ultrasound
Purpose Assess fetal health and anomalies
Sample Type Blood and ultrasound
Preparation No specific preparation needed
Fasting Not typically required
Gender Female
Age Group Pregnant individuals
Normal Value Risk Below Cut-off
Reporting Time Within a few days
Cost 1000-2000 INR*

*First Trimester Screening Test Price range may vary as per location, lab type, and procedure of lab test.

 

First Trimester Screening Test Means

The First Trimester Screening Test is a prenatal assessment conducted during early pregnancy.

  • It combines a maternal blood test and ultrasound to evaluate the developing fetus.
  • The purpose is to estimate the risk of chromosomal abnormalities, including Down syndrome.
  • This test provides crucial information for expectant parents and healthcare providers.
  • It's typically performed between 11 and 14 weeks of pregnancy.
  • Results help guide decisions about additional diagnostic testing or monitoring.

 

First Trimester Screening Test Purpose

The purpose of the First Trimester Screening Test is to:

  • Evaluate the risk of chromosomal abnormalities.
  • Assess fetal health during early pregnancy.
  • Aid in informed decision-making for expectant parents.
  • Identify potential issues, such as Down syndrome.
  • Offer a non-invasive, early pregnancy assessment.
  • Guide further diagnostic testing or intervention.

First Trimester Screening Test_ Price, Normal Range, Result, Purpose, Procedure Meaning and Interpretation - Drlogy Test

 

First Trimester Screening Test Preparation

Here is the basic preparation for the First Trimester Screening Test.

 

Before Test

  • No special preparation is needed before the test.
  • Be prepared to provide information about your medical history and the first day of your last menstrual period.

 

During Test

  • The test typically involves a maternal blood draw and an ultrasound, which are generally well-tolerated.
  • You may need to expose your abdomen for the ultrasound.

 

After Test

  • There are usually no post-test restrictions.
  • Await the results and discuss them with your healthcare provider to determine any necessary follow-up or additional tests.

 

First Trimester Screening Test Procedure

Here is the basic First Trimester Screening Test Procedure.

  • The First Trimester Screening Test involves two components: a maternal blood test and an ultrasound.
  • The maternal blood test measures specific markers in the blood, such as pregnancy-associated plasma protein-A (PAPP-A) and human chorionic gonadotropin (hCG).
  • The ultrasound, typically performed between 11 and 14 weeks of pregnancy, measures the nuchal translucency (a clear space at the back of the baby's neck).
  • The healthcare provider collects the maternal blood sample through a simple blood draw.
  • The ultrasound involves using a probe on the abdominal area to visualize and measure the nuchal translucency.
  • Results are typically available shortly after both components of the test are completed.
  • Based on the results, your healthcare provider will discuss the findings with you and may recommend additional testing or provide reassurance regarding the pregnancy.

 

First Trimester Screening Test Result

First Trimester Screening Test results are reported as a risk score or likelihood of a chromosomal abnormality, typically expressed as a fraction (e.g., 1 in 1,000).

  • A higher numerator indicates a higher risk (e.g., 1 in 100) of a chromosomal abnormality.
  • A lower numerator (e.g., 1 in 10,000) suggests a lower risk.
  • The denominator represents the average risk in the general population.
  • Your healthcare provider will explain the results, and you can discuss any concerns or potential follow-up tests.
  • The results help assess the likelihood of chromosomal abnormalities like Down syndrome, but they do not provide a definitive diagnosis.

 

First Trimester Screening Test Normal Result

Here is the normal result of the First Trimester Screening Test

Screening Test Result Interpretation
Risk Below Cut-off The calculated risk is lower than the defined cut-off value, indicating a lower likelihood of chromosomal abnormalities.

 

First Trimester Screening Test Interpretation

Here is the Interpretation of the First Trimester Screening Test.

Screening Test Result Interpretation
High Risk The calculated risk is significantly elevated, indicating an increased likelihood of chromosomal abnormalities. Further diagnostic tests are typically recommended.
Intermediate Risk The calculated risk falls within an intermediate range. Additional testing or counseling may be offered to assess the need for further evaluation.
Low Risk The calculated risk is lower, indicating a reduced likelihood of chromosomal abnormalities. This does not rule out all risks but suggests a lower likelihood.

 

First Trimester Screening Test High Risk

Here are potential causes for high risk results on a first-trimester screening test.

Potential Cause Description
Chromosomal Abnormalities Elevated risk of conditions like Down syndrome or trisomy 18.
Advanced Maternal Age Increased risk with older pregnancies.
Abnormal Ultrasound Findings Identified structural or growth abnormalities.
Previous Pregnancy with Chromosomal Abnormality A history of a previous pregnancy with a chromosomal disorder.
Family History of Genetic Conditions A family history of genetic or chromosomal conditions.
Abnormal Blood Test Results Abnormal levels of markers such as PAPP-A and hCG.
Smoking or Substance Use During Pregnancy Risk factors such as smoking or substance use.

 

First Trimester Screening Test Low Risk

Here are potential causes for low risk results on a first-trimester screening test.

Potential Cause Description
Normal Chromosomal Status No evidence of chromosomal abnormalities in the screen.
Young Maternal Age Decreased risk in younger pregnancies.
Normal Ultrasound Findings Absence of structural or growth abnormalities.
Negative Family History No family history of genetic or chromosomal conditions.
Normal Blood Test Results Normal levels of markers such as PAPP-A and hCG.
Healthy Lifestyle and Care Positive maternal health practices and prenatal care.

 

Specimen Requirements For First Trimester Screening Test

Here are the specimen requirements for the First Trimester Screening Test.

Specimen

Serum

Volume

1 ml

Container

Gel-barrier tube

Collection

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation.

Storage

Room temperature

Sample Stability

Temperature

Period

Room temperature

7 day

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type

 

First Trimester Screening Test is Safe?

The First Trimester Screening Test, a combination of a maternal blood test and ultrasound, is safe.

  • Both components of the test are non-invasive and well-tolerated by expectant mothers.
  • The benefits of early pregnancy assessment in identifying potential issues like chromosomal abnormalities outweigh the minimal risks.

 

When Do You Get First Trimester Screening Test Results? 

  • Results of the First Trimester Screening Test are typically provided shortly after both components of the test (blood test and ultrasound) are completed.
  • The reporting time may vary by healthcare provider and laboratory.

 

First Trimester Screening Test Limitation

Here is the basic limitation of First Trimester Screening Test.

  • Screening, not diagnostic: The test estimates the risk of chromosomal abnormalities but doesn't provide a definitive diagnosis.
  • False positives: It may suggest a higher risk than actual, leading to unnecessary concern and follow-up testing.
  • False negatives: Some affected pregnancies may not be identified, resulting in missed cases.
  • Variability: Factors like maternal age and obesity can affect the accuracy of risk assessment.
  • Follow-up needed: Abnormal results require additional diagnostic tests for confirmation.

 

First Trimester Screening Test Risk Factors

Here are some of the risk factors of the First Trimester Screening Test.

  • Estimates risk, not a diagnostic tool.
  • Potential for false positives and false negatives.
  • Variability in risk based on maternal age and other factors.
  • Abnormal results may lead to unnecessary concern.
  • Follow-up diagnostic tests required for confirmation.

 

Doctor Recommendations After First Trimester Screening Test Result

 Here are the Doctor's recommendations or consult a specialist after the First Trimester Screening Test.

First Trimester Screening Test Doctor to Visit Reason
High Risk Obstetrician Comprehensive prenatal care and testing.
Normal Risk Obstetrician Routine prenatal care and monitoring.
Low Risk Obstetrician Routine prenatal care and monitoring.

 

First Trimester Screening Test Price

Here are the estimated First Trimester Screening Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

1000-2000

New Delhi

1200-2000

Bangalore

1000-2000

Hyderabad

1200-2000

Kolkata

1000-2000

Pune

1200-2000

Lucknow

1000-2000

Noida

1200-2000

Surat

1200-2000

Gurugram

1000-2000

Patna

1200-2000

Chennai

1000-2000

Jaipur

1200-2000

Ahmedabad

1000-2000

*First Trimester Screening Test Price are approximate and vary depending on a specific laboratory or healthcare facility.

 

 

Summary

Overall, First Trimester Screening Test aids in early assessment of fetal health, estimating chromosomal abnormality risk, and informing crucial decisions during pregnancy. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • First Trimester Screening Test - Wikipedia [1].
  • First Trimester Screening Test - NIH [2].

 

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First Trimester Screening Test FAQ

What tests are done in first trimester screening?

The first trimester screening typically includes a combination of ultrasound and blood tests. The ultrasound measures nuchal translucency, and blood tests assess specific markers like PAPP-A and hCG.

What is the first trimester screening guideline?

The guideline involves a comprehensive assessment between 11 to 14 weeks of pregnancy. It combines the nuchal translucency measurement, maternal age, and blood test results to evaluate the risk of chromosomal abnormalities, especially Down syndrome.

How is first trimester screening calculated?

The screening calculates the risk by considering factors like maternal age, nuchal translucency measurement from ultrasound, and blood markers (PAPP-A and hCG). These parameters are integrated into a formula to estimate the likelihood of chromosomal abnormalities.

What are the first trimester screening markers?

Key markers include maternal serum PAPP-A (pregnancy-associated plasma protein-A) and hCG (human chorionic gonadotropin). Abnormal levels of these proteins, along with nuchal translucency, contribute to the overall risk assessment for chromosomal abnormalities in the fetus.

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