Des-gamma-carboxy prothrombin (DCP) Test For Liver Cancer

Des-gamma-carboxy prothrombin (DCP) Test For Liver Cancer

The DCP test is a blood test used to detect the presence of a protein called des-gamma-carboxy prothrombin, which can be elevated in liver cancer. It aids in the diagnosis and monitoring of hepatocellular carcinoma (a common form of liver cancer).

 

DCP Test

Here are the basic details of the DCP Test.

Also Known As Des-gamma-carboxy prothrombin Test
Type Blood test
Purpose Detect liver cancer marker
Sample Type Blood serum
Preparation No specific preparation
Fasting Typically not required
Gender All
Age Group All 
Normal Value <7.5 ng/mL
Reporting Time Few Days
Cost 3000-5000 INR*

*DCP Test Price range may vary as per location, lab type, and procedure of lab test.

 

DCP Test Means

Des-gamma-carboxy prothrombin (DCP) Test Measures the presence of DCP in the blood.

  • Important in the diagnosis and monitoring of liver cancer (Hepatocellular carcinoma).
  • Helps detect liver cancer at an early, potentially treatable stage.
  • Used in conjunction with other liver cancer screening methods.
  • Assists in assessing treatment responses and recurrence.
  • Valuable for individuals at risk of liver cancer.

 

DCP Test Purpose

The purpose of the DCP Test is to:

  • Diagnose and monitor liver cancer (Hepatocellular carcinoma).
  • Detect liver cancer at an early, treatable stage.
  • Assist in assessing treatment responses and recurrence.
  • Used in combination with other liver cancer screening methods.
  • Valuable for individuals at risk of liver cancer.

 

DCP Test- Price, Normal Range, Result, Purpose, Procedure Meaning and Interpretation - Drlogy Test

 

DCP Test Preparation

Here is the basic preparation for the DCP Test.

 

Before Test

  • Consult with your healthcare provider to discuss the test and its purpose.
  • Share your medical history, including any liver conditions, medications, and recent medical procedures.
  • Follow any specific pre-test instructions, such as fasting or medication adjustments, provided by your healthcare provider.
  • Ensure the clinic or hospital has access to your complete medical records.
  • Be prepared for blood sample collection, as this test typically involves a blood draw.

 

During Test

  • Arrive at the clinic or hospital at the appointed time.
  • Wear comfortable clothing that allows easy access to your arm for blood collection.
  • Remain calm and cooperative during the blood draw or sample collection.
  • Notify the medical staff of any discomfort or unusual symptoms experienced during the test.
  • The test involves a relatively quick and routine blood collection procedure.

 

After Test

  • Stay at the clinic or hospital for any recommended observation or recovery period, if necessary.
  • Resume your regular activities unless otherwise instructed by your healthcare provider.
  • Schedule a follow-up appointment with your healthcare provider to discuss the test results.
  • Review the implications of the test results for any liver condition diagnosis or monitoring.
  • Collaborate with your healthcare team to make informed decisions regarding treatment or further testing based on the DCP test outcome.

 

DCP Test Procedure

Here is the basic DCP Test Procedure.

  • Blood sample is collected.
  • The sample is processed to measure DCP levels.
  • Immunoassays or other methods are used for DCP detection.
  • Results are used for diagnosing and monitoring liver cancer.
  • Typically performed alongside other liver cancer screening methods.

 

DCP Test Result

Here is the basic reading of the Des-gamma-carboxy prothrombin (DCP) Test results.

  • DCP Levels: Check the levels of Des-gamma-carboxy prothrombin (DCP). Elevated DCP levels may indicate liver abnormalities, particularly hepatocellular carcinoma.
  • Reference Range: Compare the DCP levels in the report to the reference range provided. Values outside the reference range may be of concern.
  • Diagnosis: Look for any mention of a liver cancer diagnosis or the need for further evaluation.
  • Recommendations: Note any recommendations for additional tests, monitoring, or treatment based on the DCP test results.

 

DCP Test Normal Result Report

DES GAMMA CARBOXY PROTHROMBIN DCP Test Normal Result Report Format - Drlogy Test

DCP Test Normal Report

DCP Test Normal Result Report PDF

 

DCP Test Abnormal Result Report

DES GAMMA CARBOXY PROTHROMBIN DCP Test Abnormal Result Report Format - Drlogy Test

DCP Test Abnormal Report

DCP Test Abnormal Result Report PDF

 

DCP Test Normal Range

Here is the normal range of the DCP Test

Test Name Reference Range
Des-gamma-carboxy prothrombin (DCP) <7.5 ng/mL

 

DCP Test Interpretation

Here is the Interpretation of the DCP Test.

DCP Level (ng/mL) Interpretation
<7.5 Within the normal reference range.
7.5 - 10.0 Borderline or slightly elevated DCP levels.
>10.0 Elevated DCP levels, indicating possible issues.

 

DCP Test High Levels

Here are potential causes of high Des-gamma-carboxy prothrombin (DCP) test levels:

Potential Cause Explanation
Liver Cancer Elevated DCP levels are often associated with hepatocellular carcinoma (liver cancer).
Cirrhosis Advanced liver cirrhosis can lead to increased DCP levels due to liver damage.
Liver Dysfunction Any condition that impairs liver function may result in elevated DCP levels.
Chronic Hepatitis Certain types of chronic viral hepatitis (e.g., hepatitis B or C) can lead to elevated DCP levels.
Alcohol Abuse Prolonged alcohol abuse can cause liver damage, potentially leading to high DCP levels.
Other Liver Diseases Some non-cancerous liver conditions can also result in elevated DCP levels.
Medications Certain medications or drugs may affect liver function and DCP levels.

High DCP levels are typically a concerning finding and may warrant further evaluation and diagnostic tests to determine the underlying cause. 

 

DCP Test Low Levels

Here are potential causes of low Des-gamma-carboxy prothrombin (DCP) test levels:

Potential Cause Explanation
Vitamin K Deficiency Insufficient vitamin K in the body can result in reduced DCP levels as it is necessary for the carboxylation of prothrombin.
Malabsorption Disorders Conditions that impair the absorption of vitamin K, such as celiac disease or Crohn's disease, can lead to low DCP levels.
Warfarin or Blood Thinners Medications like warfarin (Coumadin) interfere with the coagulation process and can cause decreased DCP levels.
Liver Disease Severe liver dysfunction, particularly in advanced cirrhosis, may lead to reduced synthesis of DCP.
Underlying Coagulopathy Conditions affecting blood coagulation may indirectly impact DCP levels.
Rare Genetic Disorders Certain rare genetic disorders can affect the production or functioning of prothrombin.
Hemorrhagic Disorders Some bleeding disorders can result in low DCP levels due to excessive bleeding.

Low DCP levels should be interpreted in the context of the patient's overall health and medical history, and further investigation may be necessary to identify the underlying cause.

 

Specimen Requirements For DCP Test

Here are the specimen requirements for the DCP Test.

Specimen

Serum Frozen

Volume

0.5 ml

Container

Red-top tube or gel-barrier tube

Collection

Separate serum from cells and transfer to a plastic transport tube.

Storage

Freeze.

Causes for Rejection

Gross icterus; gross hemolysis.

 

DCP Test is Safe?

The DCP test is safe and involves a routine blood sample collection.

  • There are no specific risks or side effects associated with the test itself.
  • Patient safety is a priority, and medical professionals ensure proper blood collection and processing.

 

When Do You Get DCP Test Results? 

  • DCP test results are typically available within a few days after the blood sample is collected.
  • Patients can discuss the results and their implications during a follow-up appointment with their healthcare provider.

 

DCP Test Limitation

Here is the basic limitation of DCP Test.

  • Elevated DCP levels are not exclusive to liver cancer.
  • False positives can occur, leading to unnecessary concern.
  • Limited as a standalone diagnostic tool.
  • Cannot differentiate between liver cancer stages.
  • May require confirmation with additional tests or imaging.

 

DCP Test Risk Factors

Here are some of the risk factors of the DCP Test.

  • Minimal risk associated with a routine blood draw.
  • Possible false positives or false negatives.
  • DCP elevation is not specific to liver cancer.
  • Limitations in differentiating between liver diseases.
  • Risk of misinterpretation without considering clinical context.

 

Doctor Recommendations After DCP Test Result

 Here are the Doctor's recommendations or consult a specialist after the DCP Test.

DCP Test Result Doctor to Consult Reason to Go to Doctor
High Hepatologist Evaluate liver health.
Normal Primary Care Routine health assessment.
Low Hematologist Investigate bleeding disorders.

 

DCP Test Price

Here are the estimated DCP Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

3000-5000

New Delhi

3200-5000

Bangalore

3000-5000

Hyderabad

3200-5000

Kolkata

3000-5000

Pune

3200-5000

Lucknow

3000-5000

Noida

3200-5000

Surat

3200-5000

Gurugram

3000-5000

Patna

3200-5000

Chennai

3000-5000

Jaipur

3200-5000

Ahmedabad

3000-5000

*DCP Test Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, DCP Test play a crucial role in the early detection and monitoring of liver cancer, facilitating timely interventions and improved patient outcomes. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Des-gamma carboxyprothrombin - Wikipedia [1].
  • A Systematic Review of Des-γ-Carboxy Prothrombin for the Diagnosis of Primary Hepatocellular Carcinoma - NIH [2].

 

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DCP Test FAQ

Can a normal DCP result rule out liver cancer?

A normal DCP result does not definitively rule out liver cancer. It is a valuable tool, but other diagnostic tests and imaging may be necessary to ensure a comprehensive evaluation and potentially rule out the presence of cancer.

What is the DCP test for liver cancer?

The DCP test, also known as PIVKA-II, measures the blood levels of Des-gamma-carboxy prothrombin, a protein associated with liver cancer. Elevated DCP levels can indicate the presence of liver cancer.

How is the DCP test performed?

A blood sample is taken from a patient's vein, and the serum is analyzed to measure DCP levels. The test is typically conducted in a clinical laboratory.

Is the DCP test invasive?

The DCP test is not considered invasive. It involves a simple blood draw, and patients usually experience minimal discomfort. The procedure is well-tolerated, and the risk of complications is generally very low.

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