Activated Partial Thromboplastin Time (APTT) Test For Blood Clot Time

Activated Partial Thromboplastin Time (APTT) Test For Blood Clot Time

The APTT test is a blood test that checks how quickly blood clots. It helps doctors diagnose and manage bleeding disorders and ensures the right dose of blood-thinning medications like heparin.

 

APTT Test

Here are the basic details of the APTT Test.

Also Known As Activated Partial Thromboplastin Time
Type Blood Test
Purpose Assess clotting ability, diagnose bleeding disorders
Sample Type Blood (plasma)
Preparation No
Fasting No
Gender Unisex
Age Group All
Normal Value 23.7 - 33.0 sec
Reporting Time A few hours or A day
Cost 300-600 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

 

APTT Test Means

APTT Test, or Activated Partial Thromboplastin Time Test, assesses blood clotting speed to diagnose bleeding disorders and monitor heparin therapy.

  • APTT Test measures intrinsic and common clotting pathways.
  • It involves adding calcium and phospholipid to a plasma sample.
  • Normal APTT Test range is 27.0–41.0 seconds, but it varies for heparin therapy.
  • APTT Test is vital in preventing excessive bleeding during surgeries and ensuring heparin's therapeutic effect.



APTT Test Purpose

The purpose of the APTT Test is to:

  • Assess blood clotting speed.
  • Diagnose bleeding disorders.
  • Monitor effectiveness of heparin therapy.
  • Ensure proper blood clotting during surgeries.
  • Identify clotting factor deficiencies or abnormalities.

APTT Test Price, Normal Range, Result, Purpose, Meaning and Interpretation - Drlogy Test

 

APTT Test Preparation

Here is the basic preparation for the APTT Test.

 

Before Test

  • No fasting or special dietary restrictions are typically required.
  • Inform your healthcare provider about any medications or supplements you are taking.
  • Wear clothing with easy access to your arm, as a blood sample is usually drawn from a vein in your arm.

 

During Test

  • You'll be seated comfortably.
  • A healthcare professional will use a needle to draw a blood sample from your arm.
  • You may feel a brief pinch or sting when the needle is inserted.

 

After Test

  • Apply pressure to the site of the needle puncture to minimize bleeding.
  • You can resume normal activities unless your healthcare provider advises otherwise.
  • Results will be reported to your healthcare provider for interpretation and discussion.

 

APTT Test Procedure

Here is the basic APTT Test Procedure.

  • Blood sample drawn from your arm.
  • Sample mixed with calcium and phospholipid.
  • Time measured for clot formation in seconds.
  • Results used to assess clotting function.

 

APTT Test Result

  • A normal APTT result is typically ≤35 seconds, but ranges can vary.
  • A typical APTT value falls between 30-40 seconds. On heparin, it's 60-80 seconds.
  • Prolonged APTT suggests delayed clotting and may indicate various conditions like bleeding disorders, liver disease, or medication usage.

 

APTT Test Report

APTT test report format example sample template- drlogy lab report

APTT Test Report PDF

 

APTT Test Normal Report

Activated Partial Thromboplastin Time Aptt Normal Test Report Format Example Sample Template - Drlogy Pathology Lab Report Format

APTT Normal Test Report PDF Format

APTT Test Normal Result Report PDF

 

APTT Test Abnormal Report

Activated Partial Thromboplastin Time Aptt Abnormal Test Report Format Example Sample Template - Drlogy Pathology Lab Report Format

APTT Abnormal Test Report PDF Format

APTT Test Abnormal Result Report PDF

 

APTT Test Normal Range

Here is the normal range of the APTT Test.

APTT Level Normal Range
23.7 - 33.0 sec Common reference range for APTT in many cases

 

APTT Test Interpretation

Here is the Interpretation of the APTT Test.

APTT Test Result Interpretation
Less than or equal to 23.7 sec Typically considered normal, but individual ranges may vary
23.7 - 33.0 sec Common reference range for APTT in many cases.
> 33 sec (On heparin) Target range for patients undergoing heparin therapy

The APTT test measures blood clotting time, with normal results typically ≤35 seconds and variations indicating potential clotting disorders or therapeutic heparin use.

 

APTT Test High Levels

Here are some possible causes of high APTT levels:

Possible Causes Interpretation
Heparin therapy or anticoagulant use Within the expected range for treatment.
Bleeding disorders (e.g., hemophilia, DIC) Indicates impaired blood clotting.
Liver disease Liver dysfunction affecting clotting.
Coagulation factor deficiencies or inhibitors May lead to prolonged clotting times.
Vitamin K deficiency Affecting factors needed for clotting.
Diffuse intravascular coagulation (DIC) Widespread abnormal clot formation.

High APTT levels may result from various causes, including therapy, bleeding disorders, liver disease, coagulation factor issues, vitamin K deficiency, or DIC.

 

APTT Test Low Levels

Here are some possible causes of low APTT levels:

Possible Causes Interpretation
Lupus anticoagulant or antiphospholipid syndrome Can cause a falsely prolonged APTT.
Clotting factor excess (e.g., Factor V Leiden) May lead to a shorter clotting time.
Specific medications (e.g., high-dose heparin) Shortened APTT due to anticoagulant effects.
Technical issues or sample contamination May result in inaccurate APTT readings.
Rare congenital conditions Genetic disorders can affect clotting time.

Low APTT levels can be caused by conditions like lupus anticoagulant, clotting factor excess, medications, technical issues, or rare congenital disorders.

 

Specimen Requirements For APTT Test

Here are the specimen requirements for the APTT Test.

Specimen

Whole blood or plasma

Volume

4.5 mL, 2.7 mL, 1.8 mL

Container

Blue-top (sodium citrate) tube

Collection

Use blue-top tubes with sodium citrate. Mix gently. No discard tube needed unless using a winged collection system.

Storage

Room temperature

Sample Stability

Temperature

Period

Room temperature

24 hours

Causes for Rejection

Gross hemolysis; clotted specimen; frozen specimen thawed in transit; tubes <90% full; improper labeling

 

APTT Test is Safe?

The Activated Partial Thromboplastin Time test is generally safe.

  • It involves a routine blood draw, which may cause mild discomfort or bruising at the needle site.
  • Risks are minimal, and complications are rare, with the benefits of diagnosis and treatment outweighing potential discomfort.

 

When Do You Get APTT Test Results? 

  • APTT test results are typically available within a few hours to a day.
  • Turnaround time may vary depending on the laboratory's workload and location.
  • Healthcare providers will communicate the results and provide interpretation.

 

APTT Test Limitation

Here is the basic limitation of APTT Test.

  • Limited by specific reagents and laboratory techniques.
  • May not identify all bleeding disorders.
  • Results vary with equipment and reference ranges.
  • Interpretation requires clinical context.
  • Not a standalone diagnostic test; used in conjunction.

 

APTT Test Risk Factors

Here are some of the risk factors of the APTT Test.

  • Minimal risks associated with standard blood draw procedure.
  • Rare complications such as infection or bleeding.
  • Discomfort or bruising at the needle insertion site.
  • No major health risks associated with APTT testing.
  • Benefits outweigh minimal risks for diagnosis and treatment.

 

Doctor Recommendations After APTT Test Result

 Here are the Doctor's recommendations or consult a specialist after the APTT Test.

APTT Result Doctor to Visit Reason
High Hematologist Evaluate bleeding disorders.
Normal No specific doctor Routine or follow-up testing.
Low Hematologist Investigate clotting issues.

Visit a hematologist for high or low APTT results to assess clotting or bleeding disorders, while normal results may not require a specific doctor's visit.

 

APTT Test Price

Here are the estimated APTT Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

300-600

New Delhi

200-500

Bangalore

300-600

Hyderabad

200-500

Kolkata

300-600

Pune

200-500

Lucknow

300-600

Noida

200-500

Surat

200-500

Gurugram

300-600

Patna

200-500

Chennai

300-600

Jaipur

200-500

Ahmedabad

300-600

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, The APTT test measures blood clotting speed, aiding in diagnosing bleeding disorders or monitoring heparin therapy for optimal health. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Partial thromboplastin time - Wikipedia [1].
  • Diagnosis of Hemophilia - CDC [2].

 

 

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APTT Test FAQ

What is an APTT test?

The APTT (Activated Partial Thromboplastin Time) test is a medical laboratory test that measures the time it takes for blood to clot. It is primarily used to assess the clotting ability of the blood's intrinsic pathway, which involves various clotting factors. An APTT test helps diagnose bleeding disorders and monitor the effectiveness of anticoagulant therapy.

Why is the APTT test important?

The APTT test is crucial for diagnosing and monitoring bleeding disorders and assessing clotting factors. It helps healthcare providers identify conditions like hemophilia, liver disease, and clotting factor deficiencies. Monitoring APTT levels in patients on anticoagulant therapy ensures the medication's proper dosage and effectiveness.

How is the APTT test performed?

During the APTT test, a blood sample is drawn from a vein in the arm. It is then mixed with a substance that initiates clotting. The time it takes for a clot to form is measured. The results are typically reported in seconds, and a longer APTT time may indicate a clotting disorder.

What are the normal APTT values?

The normal range for APTT values can vary slightly depending on the laboratory and the reagents used. Generally, a normal APTT falls within the range of 25 to 35 seconds. However, it's crucial to refer to the specific reference range provided by your healthcare provider or lab for accurate interpretation.

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