Antithrombin Test For Blood Clotting Disorders

The antithrombin test assesses a protein's quantity and function to diagnose excessive blood clotting disorders and investigate recurrent blood clots.

Antithrombin Test

Here are the basic details of the Antithrombin Test.

Also Known As	AT III Test
Type	Blood Test
Purpose	Evaluate Blood Clotting
Sample Type	Blood
Preparation	None
Fasting	Not Required
Gender	All
Age Group	All
Normal Value	80% - 120%
Reporting Time	Within 24 hrs
Cost	1000-3000 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

Antithrombin Test Means

The Antithrombin Test assesses antithrombin III levels.

It Measures blood's ability to prevent clotting.
Involves a simple blood sample collection.
No special preparation or fasting is usually required.
It helps diagnose clotting disorders and monitor treatment.

Antithrombin Test Purpose

The purpose of the Antithrombin Test is to:

Evaluate blood clotting function.
Diagnose clotting disorders.
Monitor antithrombin III levels.
Assess risk of excessive clotting.
Guide treatment for blood disorders.

Antithrombin Test Price, Normal Range, Result, Purpose, Procedure Meaning and Interpretation - Drlogy Test

Antithrombin Test Preparation

Here is the basic preparation for the Antithrombin Test.

Before Test

No specific dietary restrictions or fasting are typically required.
Inform your healthcare provider about any medications or supplements you are taking, especially anticoagulants or blood thinners.
Share your medical history and recent illnesses with your doctor.

During Test

A healthcare professional collects a blood sample from a vein in your arm.
You may experience a temporary needle prick or mild discomfort during the blood draw.

After Test

A healthcare professional collects a blood sample from a vein in your arm.
You may experience a temporary needle prick or mild discomfort during the blood draw.

Antithrombin Test Procedure

Here is the basic Antithrombin Test Procedure.

A healthcare provider collects a blood sample.
The blood sample is typically drawn from a vein in your arm.
The blood sample is sent to a laboratory for analysis.
In the lab, technicians measure the level of antithrombin III.
Results are reported as a specific numerical value.
Your doctor will interpret the results and discuss them with you during a follow-up appointment.

Antithrombin Test Result

Here's how to interpret Antithrombin Test results in basic way.

Decreased antithrombin activity and antigen: Suggests type 1 antithrombin deficiency, increasing the risk of blood clots.
Reduced antithrombin activity and normal antigen: Indicates type 2 antithrombin deficiency, leading to a higher clotting risk.
Normal antithrombin activity: Typically, no antigen test is performed, suggesting adequate antithrombin function.
Conditions affecting antithrombin levels: Various medical conditions can temporarily or chronically impact antithrombin levels, affecting clotting risk.
Increased antithrombin levels: Generally not problematic.

Antithrombin Test Normal Range

Here is the normal range of the Antithrombin Test.

Antithrombin Test	Normal Range
Antithrombin Activity	80% - 120%

Antithrombin Test Interpretation

Here is the Interpretation of the Antithrombin Test.

Antithrombin Test Result	Interpretation
Low Antithrombin Activity (<80%)	Indicates a potential risk of clotting disorders, such as antithrombin deficiency or other conditions affecting clotting regulation.
Normal Antithrombin Activity (80% - 120%)	Typically considered within the normal range, indicating an appropriate level of clotting regulation.
High Antithrombin Activity (>120%)	Elevated levels are not usually considered problematic and may result from certain conditions or medications.

Antithrombin Test High Levels

Here are potential causes of high antithrombin levels.

Potential Causes	Explanation
Genetic factors	Inherited mutations or deficiencies in antithrombin production can lead to elevated levels.
Liver disease	Liver damage or disease can impair the synthesis of antithrombin, causing levels to rise.
Pregnancy	Antithrombin levels may naturally increase during pregnancy.
Medications	Certain medications, such as heparin, can elevate antithrombin levels.
Inflammatory conditions	Inflammatory states, such as rheumatoid arthritis, can cause increased antithrombin production.
Thrombosis	Presence of blood clots or thrombosis can lead to an increase in antithrombin levels.
Acute-phase reaction	Conditions like infection or trauma can trigger an acute-phase reaction, raising antithrombin levels.
Nephrotic syndrome	Kidney disease, such as nephrotic syndrome, can cause antithrombin levels to be elevated.
Anticoagulant therapy	Patients on anticoagulant therapy may experience elevated antithrombin levels due to the medication's mechanism.
Hematological disorders	Conditions like myeloproliferative disorders can lead to elevated antithrombin levels.
Aging	Antithrombin levels may naturally increase with age.
Surgery	After surgery, antithrombin levels can temporarily rise as part of the body's response to trauma.

Please note that elevated antithrombin levels can be indicative of different underlying conditions, and further clinical evaluation is typically necessary to determine the specific cause.

Antithrombin Test Low Levels

Here are potential causes of low antithrombin levels.

Potential Causes	Explanation
Genetic deficiency	Inherited mutations or deficiencies in antithrombin production can result in low levels.
Liver disease	Liver damage or disease can impair the synthesis of antithrombin, causing levels to decrease.
Acquired deficiency	Conditions like severe liver disease, DIC (disseminated intravascular coagulation), or nephrotic syndrome can lead to acquired antithrombin deficiencies.
Medications	Some medications, such as oral contraceptives or hormone replacement therapy, can reduce antithrombin levels.
Consumptive coagulopathies	Conditions that lead to increased consumption of antithrombin, like blood clots or thrombosis, can result in lower levels.
Inflammatory conditions	Inflammatory states, such as sepsis or inflammatory bowel disease, may cause a decrease in antithrombin production.
Anticoagulant therapy	Patients on certain anticoagulant medications may experience lower antithrombin levels due to their mechanism of action.
Hemolytic uremic syndrome	This rare condition can lead to low antithrombin levels as a result of platelet activation and clot formation.
Nephrotic syndrome	Kidney disease, such as nephrotic syndrome, can result in lower antithrombin levels.
Post-surgical state	After surgery, antithrombin levels can temporarily decrease due to consumption in response to trauma.
Autoimmune disorders	Autoimmune conditions, such as antiphospholipid syndrome, can lead to reduced antithrombin levels.
Aging	Antithrombin levels may naturally decrease with age.

Low antithrombin levels can indicate an increased risk of thrombosis and other coagulation-related issues, so further medical evaluation is typically required to determine the underlying cause and appropriate treatment.

Specimen Requirements For Antithrombin Test

Here are the specimen requirements for the Antithrombin Test.

Specimen	Plasma, frozen
Volume	2 ml
Container	Blue-top (sodium citrate) tube
Collection	Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio.
Storage	Freeze.
Causes for Rejection	Severe hemolysis; improper labeling; clotted specimen; specimen diluted with IV fluids; samples thawed in transit; improper sample type; sample out of stability.

Antithrombin Test is Safe?

Antithrombin Test is generally safe and poses minimal risks.

It involves a routine blood draw, which is a common and safe procedure.
Potential side effects are limited to mild discomfort or bruising at the blood draw site, which is temporary.

When Do You Get Antithrombin Test Results?

Antithrombin Test results are typically available within 24 hrs.
Your healthcare provider will discuss the results with you during a follow-up appointment.

Antithrombin Test Limitation

Here is the basic limitation of Antithrombin Test.

Results can be affected by various factors, including medications.
It may not detect all causes of abnormal clotting.
Interpretation may require additional tests or clinical context.

Antithrombin Test Risk Factors

Here are some of the risk factors of the Antithrombin Test.

Minimal risk associated with the Antithrombin Test.
Standard blood draw, generally safe.
Rare instances of temporary bruising or infection at the blood draw site.

Doctor Recommendations After Antithrombin Test Result

Here are the Doctor's recommendations or consult a specialist after the Antithrombin Test.

Antithrombin Level	Doctor to Visit	Reason to See Doctor
High	Hematologist	Assess thrombosis risk or liver issues.
Normal	Primary Care	Routine follow-up and general health.
Low	Hematologist	Investigate bleeding or clotting issues.

Antithrombin Test Price

Here are the estimated Antithrombin Test Prices in India with different top cities:

City	Price Range (INR)*
Mumbai	1000-3000
New Delhi	1500-3000
Bangalore	1000-3000
Hyderabad	1500-3000
Kolkata	1000-3000
Pune	1500-3000
Lucknow	1000-3000
Noida	1500-3000
Surat	1500-3000
Gurugram	1000-3000
Patna	1500-3000
Chennai	1000-3000
Jaipur	1500-3000
Ahmedabad	1000-3000

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

Summary

Overall, Antithrombin Test is a low-risk blood test, is used to assess clotting function, diagnose clotting disorders, and monitor antithrombin III levels. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

Reference

Antithrombin Test - Wikipedia [1].
Antithrombin Test - NIH [2].

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Antithrombin Test FAQ

What is an Antithrombin Test?

The Antithrombin Test, also known as Antithrombin III (AT III) assay, is a blood test that measures the level of antithrombin in your blood. Antithrombin is a natural anticoagulant that helps regulate blood clotting.

Why is the Antithrombin Test important?

The Antithrombin Test is crucial because it helps assess the risk of excessive blood clotting, which can lead to conditions like deep vein thrombosis (DVT) or pulmonary embolism.

When is the Antithrombin Test typically ordered?

This test is usually ordered when a healthcare provider suspects a patient has a clotting disorder or to monitor anticoagulant therapy's effectiveness.

How is the Antithrombin Test performed?

A blood sample is taken from a vein, typically in your arm. The sample is then sent to a laboratory for analysis to measure antithrombin levels accurately.