Antineutrophil Cytoplasmic Antibodies (ANCA) Test For Autoimmune Disorders

Antineutrophil Cytoplasmic Antibodies (ANCA) Test For Autoimmune Disorders

Antineutrophil Cytoplasmic Antibodies (ANCA) Test checks for specific antibodies in the blood associated with autoimmune disorders like vasculitis, helping diagnose and monitor these conditions.

 

ANCA Test

Here are the basic details of the ANCA Test.

Also Known As ANCA Antibodies Test
Type Blood Test
Purpose Diagnose Autoimmune Diseases
Sample Type Blood
Preparation None
Fasting Not Required
Gender All
Age Group All
Normal Value Negative
Reporting Time 1-2 Days
Cost 1000-2000 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

 

ANCA Test Means

ANCA Test stands for "Anti-Neutrophil Cytoplasmic Antibodies Test"

  • It's a blood test that detects specific antibodies in the blood.
  • These antibodies target neutrophils, a type of white blood cell.
  • ANCA testing helps diagnose and monitor autoimmune diseases, such as vasculitis.
  • The presence of ANCA can indicate an autoimmune condition affecting blood vessels.

 

ANCA Test Purpose

The purpose of the ANCA Test is to:

  • Diagnose autoimmune diseases.
  • Detect vasculitis and related disorders.
  • Identify specific antibodies in blood.
  • Assess immune system abnormalities.
  • Aid in treatment planning and monitoring.

ANCA Test Price, Normal Range, Result, Purpose, Procedure Meaning and Interpretation - Drlogy Test

 

ANCA Test Preparation

Here is the basic preparation for the ANCA Test.

 

Before Test

  • No special dietary or fasting restrictions.
  • Inform your healthcare provider about any medications or supplements you are taking.
  • Discuss any medical conditions or recent illnesses with your doctor.

 

During Test

  • A healthcare professional will draw a blood sample from a vein in your arm.
  • You may feel a brief needle prick or discomfort during the blood draw.

 

After Test

  • You can resume normal activities immediately.
  • If you experience any unusual bleeding, swelling, or pain at the blood draw site, contact your healthcare provider.
  • Await the test results, which your doctor will discuss with you during a follow-up appointment.

 

ANCA Test Procedure

Here is the basic ANCA Test Procedure.

  • A healthcare provider collects a blood sample.
  • The blood is usually drawn from a vein in your arm.
  • The blood sample is sent to a laboratory for analysis.
  • In the lab, technicians test for the presence of ANCAs.
  • Results are typically reported as positive or negative.
  • Your doctor will discuss the results with you during a follow-up appointment.

 

ANCA Test Result

Here's how to interpret ANCA test results in basic way.

  • Positive Test: Indicates potential autoimmune vasculitis.
  • Specific Antibodies: PR3 or MPO may be present, helping to differentiate conditions.
  • Patterns: Different fluorescence patterns (pANCA, cANCA) provide additional insights.
  • Titer: Measures the amount of antibodies; a higher titer indicates more antibodies.
  • Disease Monitoring: ANCA levels can change but may not always correlate with disease activity. Diagnosis often requires clinical context and additional tests.

 

ANCA Test Normal Range

Here is the normal range of the ANCA Test

Test Component Normal Result
ANCA Negative
PR3 Antibodies Absent
MPO Antibodies Absent
Fluorescence Absence of specific pattern
Titer Not applicable

 

ANCA Test Interpretation

Here is the Interpretation of the ANCA Test.

ANCA Test Result Interpretation
Positive Supports a diagnosis of vasculitis (see details)
Negative Unlikely to be due to autoimmune vasculitis
pANCA Pattern May indicate MPO antibodies, associated with various conditions
cANCA Pattern May indicate PR3 antibodies, associated with specific conditions
Atypical ANCA Positive staining without typical pattern

 

ANCA Test Positive Results

Here are the potential causes of positive ANCA test results.

Positive ANCA Test Results Potential Causes
Vasculitis (Systemic Autoimmune) Support diagnosis of autoimmune vasculitis.
Granulomatosis with Polyangiitis (Wegener's) Common in patients with active granulomatosis.
Microscopic Polyangiitis Consistent with conditions like glomerulonephritis.
Eosinophilic Granulomatosis with Polyangiitis (Churg Strauss Syndrome) Associated with these conditions.
Polyarteritis Nodosa Rare but may have positive results.

These positive ANCA test results often support the diagnosis of autoimmune vasculitis and help distinguish between different types of vasculitis.

 

ANCA Test Negative Results

Here are the potential causes of negative ANCA test results which are considered normal.

Negative ANCA Test Results Potential Causes
Unlikely Autoimmune Vasculitis If symptoms suggest vasculitis, it's less likely.
Other Health Conditions Symptoms may be due to non-vasculitis causes.
Timing or Remission Cryoglobulins may not be present during the test.
Varied Cryoglobulin Presence Cryoglobulins can fluctuate in some disorders.
Confirmatory Testing Needed Negative result doesn't rule out other conditions.

A negative ANCA test result suggests that autoimmune vasculitis is less likely, but it doesn't rule out other health conditions. Additional diagnostic tests may be needed for a comprehensive diagnosis.

 

Specimen Requirements For ANCA Test

Here are the specimen requirements for the ANCA Test.

Specimen

Serum

Volume

1 ml

Container

Red-top tube or gel-barrier tube

Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Storage

Refrigerate or freeze.

Sample Stability

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

60 days

Freeze/thaw cycles

Stable x1

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types.

 

ANCA Test is Safe?

ANCA (Antineutrophil Cytoplasmic Antibody) Test is generally safe.

  • It involves a routine blood draw and poses minimal risks.
  • Side effects are typically limited to minor discomfort during the blood dra

 

When Do You Get ANCA Test Results? 

  • ANCA Test results are usually available within 1 to 2 days.
  • Your healthcare provider will discuss the results with you during a follow-up appointment.

 

ANCA Test Limitation

Here is the basic limitation of ANCA Test.

  • May yield false-positive or false-negative results.
  • Cannot provide a definitive diagnosis alone.
  • Interpretation requires clinical context.

 

ANCA Test Risk Factors

Here are some of the risk factors of the ANCA Test.

  • No specific risk factors associated with the ANCA Test.
  • Routine blood draw, minimal discomfort.
  • Rare instances of bruising or infection at the blood draw site.

 

Doctor Recommendations After ANCA Test Result

 Here are the Doctor's recommendations or consult a specialist after the ANCA Test.

ANCA Test Results Doctor to Visit Reason to Visit
Positive Rheumatologist Confirm vasculitis diagnosis.
Negative Primary Care Physician Explore other health issues.

 

ANCA Test Price

Here are the estimated ANCA Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

1000-2000

New Delhi

1200-2000

Bangalore

1000-2000

Hyderabad

1200-2000

Kolkata

1000-2000

Pune

1200-2000

Lucknow

1000-2000

Noida

1200-2000

Surat

1200-2000

Gurugram

1000-2000

Patna

1200-2000

Chennai

1000-2000

Jaipur

1200-2000

Ahmedabad

1000-2000

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

 

Summary

Overall, ANCA Test is a routine and safe blood test, aids in diagnosing autoimmune diseases and detecting conditions like vasculitis. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • ANCA Test - Wikipedia [1].
  • ANCA Test - NIH [2].
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ANCA Test FAQ

What is an ANCA test?

The ANCA test, which stands for Antineutrophil Cytoplasmic Antibodies test, is a blood test used to detect the presence of specific antibodies in the bloodstream. These antibodies are associated with autoimmune diseases, particularly those affecting the blood vessels and causing inflammation.

Why is the ANCA test performed?

The ANCA test is performed to help diagnose and monitor autoimmune diseases, such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). It can also aid in distinguishing between different types of vasculitis.

How is the ANCA test conducted?

A blood sample is collected from a vein in your arm, and the serum is separated to measure the presence of ANCA antibodies. The test is typically performed in a clinical laboratory.

How long does it take to receive ANCA test results?

ANCA test results are usually available within a few days to a week, depending on the laboratory's processing time. Your healthcare provider will discuss the results and their implications with you.

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