Antihistone Antibodies Test To Diagnose and Monitor Drug-Induced Lupus

Antihistone Antibodies Test To Diagnose and Monitor Drug-Induced Lupus

The Antihistone Antibodies Test is a medical tool used to detect specific antibodies related to autoimmune diseases. It helps doctors diagnose and distinguish these conditions in patients.

 

Antihistone Antibodies Test

Here are the basic details of the Antihistone Antibodies Test.

Also Known As Histone Antibody Test
Type Blood test
Purpose Detect autoimmune diseases and drug-induced lupus.
Sample Type Serum
Preparation No
Fasting Not required
Gender Unisex
Age Group All
Normal Value Negative
Reporting Time A few days
Cost 1000-2000 INR*

*Antihistone Antibodies Test Price range may vary as per location, lab type, and procedure of lab test.

 

Antihistone Antibodies Test Means

The Antihistone Antibodies Test is a medical examination used to detect specific antibodies related to autoimmune diseases like lupus.

  • It helps identify conditions and differentiate between drug-induced and idiopathic lupus.
  • This blood test is vital in diagnosing and monitoring various autoimmune disorders, such as rheumatoid arthritis and Sjögren's syndrome.
  • The test assesses the presence of antibodies targeting histone proteins and histone complexes in the bloodstream.
  • Results can aid in determining the appropriate treatment for patients with autoimmune conditions.

 

Antihistone Antibodies Test Purpose

The purpose of the Antihistone Antibodies Test is to:

  • Used to diagnose and monitor autoimmune diseases like lupus and related conditions.
  • Detects Specific Antibodies: Identifies antibodies targeting histone proteins and complexes in the blood.
  • Helps differentiate between drug-induced and idiopathic lupus erythematosus.
  • Assists in determining appropriate treatments for patients with autoimmune disorders.
  • Aids in early detection and management of various autoimmune conditions.

Antihistone Antibodies Test Price, Normal Range, Result, Purpose, Meaning and Interpretation - Drlogy Test

 

Antihistone Antibodies Test Preparation

Here is the basic preparation for the Antihistone Antibodies Test.

 

Before Test

  • No specific dietary or fasting requirements.
  • Inform your healthcare provider about any medications or supplements you are taking.
  • Discuss any allergies or potential concerns with the healthcare team.

 

During Test

  • A healthcare professional will draw a blood sample from your arm.
  • You may feel a brief pinch or sting during the blood draw.
  • Stay relaxed and follow the instructions provided by the healthcare provider.

 

After Test

  • You can resume your normal activities immediately.
  • It may take a few days for the results to be processed.
  • Discuss the results and any necessary follow-up with your healthcare provider.

 

Antihistone Antibodies Test Procedure

Here is the basic Antihistone Antibodies Test Procedure.

  • A healthcare professional collects a blood sample from a vein in your arm.
  • The blood sample is then sent to a laboratory for analysis.
  • In the lab, the sample is tested for the presence of specific antihistone antibodies.
  • Results are reported to your healthcare provider, who will discuss them with you.
  • The procedure is relatively quick and typically causes minimal discomfort.

 

Antihistone Antibodies Test Result

  • A positive result typically indicates the presence of antihistone antibodies in the blood.
  • The level of antibodies may be reported in units, with values above 1.5 units considered positive.
  • Results should be interpreted by a healthcare professional to determine their significance for diagnosis and treatment.

 

Antihistone Antibodies Test Normal Range

Here is the normal range of the Antihistone Antibodies Test.

Test Normal Range
Antihistone Antibodies < 1.0 units

 

Antihistone Antibodies Test Interpretation

Here is the Interpretation of the Antihistone Antibodies Test.

RESULT IN Units REMARKS
< 1.0 Negative
1.0-1.5 Weak Positive
1.6-2.5 Moderate Positive
>2.5 Strong Positive

Antihistone Antibodies Test interpretation varies from negative to strong positive based on unit values.

 

Antihistone Antibodies Test Positive

Here are potential causes of positive Antihistone Antibodies Test results:

Possible Causes Effects
Autoimmune diseases (e.g., lupus, RA) Immune system targets own tissues
Drug-induced lupus (certain medications) Antibodies triggered by medication exposure
Rheumatoid arthritis (in some cases) Elevated levels of antihistone antibodies
Sjögren syndrome, dermatomyositis, and others Potential symptom exacerbation
Alzheimer's disease and dementia (association) Research into autoimmune links

A positive Antihistone Antibodies Test is associated with autoimmune diseases, drug-induced lupus, and potential exacerbation of symptoms.

 

Antihistone Antibodies Test Negative

Here are potential causes of negative Antihistone Antibodies Test results:

Possible Causes Effects
Absence of autoimmune diseases or lupus No autoimmune antibodies detected
No exposure to medications that induce lupus Absence of specific drug-induced antibodies
Not having certain autoimmune conditions Lack of evidence of these antibodies
Healthy individuals without autoimmune issues No autoimmune markers found in the blood
Lack of association with Alzheimer's and dementia No confirmed autoimmune link

A negative Antihistone Antibodies Test indicates the absence of autoimmune markers and certain related conditions.

 

Specimen Requirements For Antihistone Antibodies Test

Here are the specimen requirements for the Antihistone Antibodies Test.

Specimen

Serum

Volume

1 ml

Container

Red-top tube or gel-barrier tube

Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Storage

Room temperature

Sample Stability

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; icterus; lipemia; bacterial contamination

 

Antihistone Antibodies Test is Safe?

  • The Antihistone Antibodies Test is generally safe.
  • It involves a routine blood draw, which carries minimal risk.
  • However, discuss any concerns or allergies with your healthcare provider before the test.

 

When Do You Get Antihistone Antibodies Test Results? 

  • Antihistone Antibodies Test results are typically available within a few days.
  • The exact turnaround time can vary depending on the laboratory and healthcare provider.
  • Your healthcare provider will inform you when the results are ready for discussion.

 

Antihistone Antibodies Test Limitation

Here is the basic limitation of Antihistone Antibodies Test.

  • May not provide a definitive diagnosis on its own.
  • Results should be interpreted in conjunction with clinical evaluation.
  • False positives and negatives are possible.
  • Specificity is a limitation as it can be found in various conditions.
  • Results alone may not determine the severity or prognosis of a condition.

 

Antihistone Antibodies Test Risk Factors

Here are some of the risk factors of the Antihistone Antibodies Test.

  • No specific risk factors associated with the test itself.
  • However, the test is performed to detect autoimmune diseases, which may have various risk factors.
  • Risk factors for autoimmune diseases include genetics, gender, age, and environmental triggers.
  • Some medications may induce the production of antihistone antibodies, leading to a positive test result.
  • Discuss any underlying health conditions or medication use with your healthcare provider before the test.

 

Doctor Recommendations After Antihistone Antibodies Test Result

 Here are the Doctor's recommendations or consult a specialist after the Antihistone Antibodies Test.

Test Result Doctor to Visit Reason
Positive Rheumatologist Evaluate for treatment
Negative Not necessary No significant findings

 

Antihistone Antibodies Test Price

Here are the estimated Antihistone Antibodies Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

1000-2000

New Delhi

1500-2000

Bangalore

1000-2000

Hyderabad

1500-2000

Kolkata

1000-2000

Pune

1500-2000

Lucknow

1000-2000

Noida

1500-2000

Surat

1500-2000

Gurugram

1000-2000

Patna

1500-2000

Chennai

1000-2000

Jaipur

1500-2000

Ahmedabad

1000-2000

*Antihistone Antibodies Test Price are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, The Antihistone Antibodies Test detects specific antibodies related to autoimmune diseases. Results guide diagnosis and treatment, helping differentiate conditions like lupus. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Anti-histone antibodies - Wikipedia [1].
  • Antibodies to histone in the pediatric population - NIH [2].
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Antihistone Antibodies Test FAQ

What are Antihistone Antibodies?

Antihistone antibodies are autoantibodies that target histones, proteins associated with DNA in the cell's nucleus. These antibodies are often measured through blood tests to diagnose autoimmune conditions, especially systemic lupus erythematosus (SLE) and drug-induced lupus.

Why are Antihistone Antibodies important?

Antihistone antibodies play a crucial role in diagnosing autoimmune diseases, as their presence can indicate underlying conditions like lupus. Identifying these antibodies helps clinicians make early and accurate diagnoses, guiding treatment decisions.

How is the Antihistone Antibodies test done?

The test involves a simple blood draw, typically from a vein in your arm. The collected sample is then sent to a laboratory for analysis. It's a routine and minimally invasive procedure.

Are Antihistone Antibodies specific to lupus?

While elevated antihistone antibodies are strongly associated with lupus, they can also be found in drug-induced lupus and, less commonly, in other autoimmune diseases. This is why clinical context is crucial for interpreting the results.

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