Anti LKM-1 (Liver Kidney Microsomal) Antibody Test For Liver Diseases

The Anti LKM-1 Antibody Test looks for specific antibodies in your blood that are associated with autoimmune liver diseases. It helps doctors diagnose and manage these conditions.

Anti LKM-1 Antibody Test

Here are the basic details of the Anti LKM-1 Antibody Test.

Also Known As	LKM-1 Antibody Test, Liver Kidney Microsomal Antibody
Type	Blood Test
Purpose	Diagnose autoimmune liver conditions, particularly autoimmune hepatitis type 2
Sample Type	Blood sample from a vein
Preparation	Typically, no special preparation is needed
Fasting	Not applicable
Gender	All
Age Group	All
Normal Value	≤ 20.0 Units (Negative)
Reporting Time	1-2 days
Cost	2000-3000 INR*

*Anti LKM-1 Antibody Test Price range may vary as per location, lab type, and procedure of lab test.

Anti LKM-1 Antibody Test Means

Anti LKM-1 Antibody Test detects specific antibodies associated with autoimmune liver diseases, particularly autoimmune hepatitis type 2.

Aids in the diagnosis and management of autoimmune liver conditions.
Involves a blood test to identify anti-LKM-1 antibodies.
Helps differentiate autoimmune liver diseases from other liver disorders.
A positive result indicates an autoimmune response linked to autoimmune hepatitis type 2.
A negative result does not rule out the possibility of autoimmune liver disease.

Anti LKM-1 Antibody Test Purpose

The purpose of the Anti LKM-1 Antibody Test is to:

Diagnose autoimmune liver diseases, particularly autoimmune hepatitis type 2.
Distinguish autoimmune liver disorders from other liver conditions.
Monitor autoimmune hepatitis type 2 treatment and management.
Assess autoimmune response related to liver diseases.
Aid in determining appropriate therapeutic approaches.
Confirm the presence of anti-LKM-1 antibodies.

Anti LKM-1 Antibody Test Price, Normal Range, Result, Purpose, Procedure Meaning and Interpretation - Drlogy Test

Anti LKM-1 Antibody Test Preparation

Here is the basic preparation for the Anti LKM-1 Antibody Test.

Before Test

No specific preparation is usually needed.
Inform your healthcare provider about any medications or medical conditions.

During Test

A blood sample is collected from a vein.

After Test

You can resume normal activities.
Await test results for diagnosis and guidance.
Discuss results and any necessary follow-up with your healthcare provider.

Anti LKM-1 Antibody Test Procedure

Here is the basic Anti LKM-1 Antibody Test Procedure.

Involves a blood sample collected through venipuncture.
Blood is drawn from a vein using a needle.
A sample is sent to a specialized laboratory for analysis.
The test identifies the presence of anti-LKM-1 antibodies.
Aids in diagnosing autoimmune liver diseases, particularly autoimmune hepatitis type 2.
Assists in differentiating autoimmune liver disorders from other liver conditions.

Anti LKM-1 Antibody Test Result

Here's guide on how to interpret the anti-LKM-1 antibody test result:

Positive Result: Suggests a likelihood of type 2 autoimmune hepatitis.
Negative Result: Doesn't rule out type 2 autoimmune hepatitis.
Not Definitive: A positive result isn't conclusive; further evaluation is needed.
Liver Biopsy: Often required to confirm the diagnosis and assess liver damage.

Anti LKM-1 Antibody Test Normal Range

Here is the normal range of the Anti LKM-1 Antibody Test

Anti LKM-1 Antibody Level	Interpretation
≤ 20.0 Units	Negative

Anti LKM-1 Antibody Test Interpretation

Here is the Interpretation of the Anti LKM-1 Antibody Test.

Anti LKM-1 Antibody Level	Interpretation
≤ 20.0 Units	Negative result, not indicative of type 2 autoimmune hepatitis.
20.1-24.9 Units	Equivocal result, further evaluation may be required.
≥ 25.0 Units	Positive result, suggests likelihood of type 2 autoimmune hepatitis, necessitating additional assessment and diagnosis.

Anti LKM-1 Antibody Test Positive Results

Here is a potential causes of positive Anti LKM-1 antibody test results.

Potential Causes	Explanation
Autoimmune Hepatitis	Anti LKM-1 antibodies are primarily associated with autoimmune hepatitis type 2, a chronic liver disease. Positive results often indicate this condition.
Hepatitis C Infection	In some cases, individuals with hepatitis C may produce Anti LKM-1 antibodies, leading to positive test results.
Medications	Certain medications, such as nitrofurantoin or minocycline, can trigger the production of these antibodies in rare cases.
Viral Infections	Other viral infections, such as Epstein-Barr virus, can sometimes lead to positive Anti LKM-1 antibody results.
Cross-Reactivity	Cross-reactivity with other antibodies, like anti-smooth muscle antibodies, can potentially cause false-positive results. Further testing may be required to confirm the cause.
Genetic Predisposition	Some individuals may have a genetic predisposition to produce Anti LKM-1 antibodies, resulting in positive test results without an associated disease.
Overlapping Conditions	Positive Anti LKM-1 antibody results can be seen in conjunction with other autoimmune diseases, such as celiac disease or systemic lupus erythematosus.

However, consultation with a healthcare professional is necessary for a proper diagnosis and evaluation.

Anti LKM-1 Antibody Test Negative Results

Here's the meaning of negative Anti LKM-1 antibody test results.

Anti LKM-1 Antibody Result	Interpretation
Negative	Absence of Anti LKM-1 antibodies.
Type 2 Autoimmune Hepatitis Less Likely	Suggests a lower likelihood of type 2 autoimmune hepatitis.
Additional Evaluation Needed	Negative result doesn't rule out type 2 autoimmune hepatitis. Further tests or clinical assessment may be required.

Negative Anti LKM-1 antibody test results indicate a reduced likelihood of type 2 autoimmune hepatitis, but a comprehensive evaluation may still be necessary for a definitive diagnosis.

Specimen Requirements For Anti LKM-1 Antibody Test

Here are the specimen requirements for the Anti LKM-1 Antibody Test.

Specimen	Serum
Volume	1 ml
Container	Red-top tube or gel-barrier tube
Collection	Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Storage	Refrigerate or freeze.
Sample Stability	Temperature	Period
	Room temperature	7 day
	Refrigerated	14 days
	Frozen	60 days
	Freeze/thaw cycles	Stable x1
Causes for Rejection	Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

Anti LKM-1 Antibody Test is Safe?

The Anti LKM-1 antibody test is generally safe.

It is a blood test and carries minimal risk, similar to any other routine blood draw.
Discuss any concerns or potential risks with your healthcare provider before the test.

When Do You Get Anti LKM-1 Antibody Test Results?

Anti LKM-1 antibody test results are typically available within a few days to a couple of weeks after the blood sample is collected.
The precise turnaround time may vary depending on the laboratory and healthcare facility, so it's recommended to check with your healthcare provider for the specific timeframe for your test results.

Anti LKM-1 Antibody Test Limitation

Here is the basic limitation of Anti LKM-1 Antibody Test.

Limited to detecting anti LKM-1 antibodies, not all causes of liver disease.
Results should be interpreted alongside clinical and other diagnostic information.
Additional testing may be necessary for a comprehensive evaluation of liver function and autoimmune hepatitis.

Anti LKM-1 Antibody Test Risk Factors

Here are some of the risk factors of the Anti LKM-1 Antibody Test.

Risk factors for autoimmune hepatitis, which the Anti LKM-1 antibody test helps diagnose, include a family history of autoimmune diseases.
No direct risks are associated with the antibody test itself; it is a diagnostic tool used to identify specific antibodies in autoimmune hepatitis.
The test is ordered when clinical symptoms and other factors suggest autoimmune liver disease.

Doctor Recommendations After Anti LKM-1 Antibody Test Result

Here are the Doctor's recommendations or consult a specialist after the Anti LKM-1 Antibody Test.

Test Result	Doctor to Visit	Reason to Go
Positive	Hepatologist/Gastroenterologist	Confirm autoimmune hepatitis type 2.
Negative	Primary Care Physician	Further evaluation if needed.

Anti LKM-1 Antibody Test Price

Here are the estimated Anti LKM-1 Antibody Test Prices in India with different top cities:

City	Price Range (INR)*
Mumbai	100-200
New Delhi	150-200
Bangalore	100-200
Hyderabad	150-200
Kolkata	100-200
Pune	150-200
Lucknow	100-200
Noida	150-200
Surat	150-200
Gurugram	100-200
Patna	150-200
Chennai	100-200
Jaipur	150-200
Ahmedabad	100-200

*Anti LKM-1 Antibody Test Price are approximate and vary depending on a specific laboratory or healthcare facility.

Summary

Overall, Anti LKM-1 Antibody Test is valuable diagnostic test for autoimmune hepatitis type 2, aiding in early detection and treatment planning. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

Reference

Anti LKM-1 Antibody Test - Wikipedia [1].
Anti LKM-1 Antibody Test - NIH [2].

5011 Likes

Feedback:

Anti LKM-1 Antibody Test FAQ

What is an Anti LKM-1 Antibody Test?

The Anti LKM-1 Antibody Test is a diagnostic blood test used to detect the presence of antibodies against liver-kidney microsomes, specifically LKM-1. These antibodies are associated with autoimmune liver diseases, such as autoimmune hepatitis type 2. The test helps in diagnosing and monitoring such conditions.

Why is the Anti LKM-1 Antibody Test important?

This test is crucial for identifying autoimmune hepatitis type 2 and distinguishing it from other liver diseases. Early detection allows for timely intervention and appropriate treatment, which can help manage the disease effectively and prevent complications.

What is the cost of the Anti LKM-1 Antibody Test?

The cost of the test can vary widely depending on factors such as your location, healthcare provider, and insurance coverage. It's best to check with your healthcare provider and insurance company for cost-related information.

What is the accuracy of the Anti LKM-1 Antibody Test?

The test is highly specific for autoimmune hepatitis type 2 when anti-LKM-1 antibodies are present, making it a reliable diagnostic tool. However, like any medical test, there can be rare instances of false positives or false negatives.