Anti-dsDNA Test To Help Diagnose and Monitor Lupus

Anti-dsDNA Test To Help Diagnose and Monitor Lupus

The Anti-dsDNA test checks for antibodies related to lupus, an autoimmune disease. It helps diagnose and monitor the condition in non-medical terms.

 

Anti-dsDNA Test

Here are the basic details of the Anti-dsDNA Test.

Also Known As Anti-dsDNA Antibody Test
Type Blood test
Purpose Diagnose and monitor autoimmune disorders
Sample Type Serum
Preparation No
Fasting Not required
Gender Unisex
Age Group All
Normal Value Negative
Reporting Time 2-3 days
Cost 850-1700 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

 

Anti-dsDNA Test Means

The Anti-dsDNA Test detects antibodies against double-stranded DNA in the blood.

  • It is crucial for diagnosing systemic lupus erythematosus (SLE), a complex autoimmune disease.
  • Elevated levels indicate SLE and monitor disease activity.
  • Used to assess treatment effectiveness and adjust therapies.
  • An essential tool for managing lupus and improving patient outcomes.

 

Anti-dsDNA Test Purpose

The purpose of the Anti-dsDNA Test is to:

  • Assesses antibodies against double-stranded DNA.
  • Diagnose and monitor lupus, an autoimmune disease.
  • Detects lupus flare-ups and guides treatment.
  • Evaluates disease severity and response to therapy.
  • Essential for lupus management and ensuring appropriate care.

Anti-dsDNA Test_ Price, Normal Range, Result, Purpose, Meaning and Interpretation - Drlogy Test

 

Anti-dsDNA Test Preparation

Here is the basic preparation for the Anti-dsDNA Test.

 

Before Test

  • No specific fasting or dietary restrictions are required.
  • Inform your healthcare provider about any medications you're taking.
  • Ensure your medical history is up-to-date.

 

During Test

  • A blood sample will be taken from a vein in your arm.
  • Stay relaxed and follow the technician's instructions.

 

After Test

  • You can resume normal activities immediately.
  • Monitor the test results as advised by your healthcare provider.
  • Discuss the results and any necessary follow-up with your doctor.

 

Anti-dsDNA Test Procedure

Here is the basic Anti-dsDNA Test Procedure.

  • Blood sample is drawn from a vein, often in the arm.
  • The sample is then sent to a lab for analysis.
  • Results are typically available in a few days.

 

Anti-dsDNA Test Result

  • High anti-dsDNA levels often indicate lupus, particularly during flare-ups.
  • Very low levels may be considered negative, but not all lupus cases show this.
  • Moderate levels can be seen in other autoimmune disorders like Sjögren's and MCTD.

 

Anti-dsDNA Test Normal Range

Here is the normal range of the Anti-dsDNA Test.

Test Normal Range
Anti-dsDNA Test Negative: <30.0 IU/mL
  Borderline: 30.0-75.0 IU/mL
  Positive: >75.0 IU/mL

 

Anti-dsDNA Test Interpretation

Here is the Interpretation of the Anti-dsDNA Test.

Result Interpretation
High Levels Suggestive of lupus, especially during flare-ups.
Very Low Levels Typically considered negative, but not in all lupus cases.
Moderate Levels May be seen in other autoimmune disorders.

Anti-dsDNA Test high levels often indicate lupus, very low levels are typically negative, while moderate levels can be linked to other autoimmune disorders.

 

Anti-dsDNA Test High Levels

Here are some possible causes of high Anti-dsDNA levels:

Possible Causes Effects
Systemic Lupus Erythematosus (SLE) Strong association with lupus, especially during flare-ups.
Lupus Nephritis Associated with ongoing kidney inflammation and damage in lupus.
Autoimmune Disorders Can sometimes indicate other autoimmune conditions.

High levels of anti-dsDNA in the blood are primarily caused by systemic lupus erythematosus (SLE), lupus nephritis, or other autoimmune disorders.

 

Anti-dsDNA Test Low Levels

Here are some possible causes of low Anti-dsDNA levels:

Cause Effects
Medications, Remission Reduced risk of lupus flares.
Early Lupus, Certain Cancers Low dsDNA levels, less diagnostic of lupus.
Potential False Negative Results Limited diagnostic accuracy for lupus.

Low Anti-dsDNA levels can result from medications, remission, early lupus, or certain cancers, potentially leading to false-negative test results for lupus.

 

Specimen Requirements For Anti-dsDNA Test

Here are the specimen requirements for the Anti-dsDNA Test.

Specimen

Serum

Volume

1 ml

Container

Red-top tube or gel-barrier tube

Storage

Room temperature

Sample Stability

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; icterus; lipemia; bacterial contamination.

 

Anti-dsDNA Test is Safe?

  • Anti-dsDNA Test is generally safe and minimally invasive.
  • It involves a routine blood draw, similar to common lab tests.
  • Risks are minimal, such as minor discomfort or bruising at the injection site.

 

When Do You Get Anti-dsDNA Test Results? 

  • Anti-dsDNA Test results typically take 2-3 days to process.
  • Timelines may vary depending on the lab or healthcare facility.
  • Prompt reporting allows for timely diagnosis and treatment planning.

 

Anti-dsDNA Test Limitation

Here is the basic limitation of Anti-dsDNA Test.

  • False positives can occur.
  • May not detect all lupus cases.
  • Results should be interpreted with clinical context.
  • Varied sensitivity and specificity.
  • Additional tests often needed for a definitive diagnosis.

 

Anti-dsDNA Test Risk Factors

Here are some of the risk factors of the Anti-dsDNA Test.

  • Autoimmune diseases like lupus elevate risk.
  • Family history of autoimmune disorders.
  • Gender: More common in women.
  • Ultraviolet light exposure.
  • Certain medications, smoking, and infections linked to increased risk.

 

Doctor Recommendations After Anti-dsDNA Test Result

 Here are the Doctor's recommendations or consult a specialist after the Anti-dsDNA Test.

Test Result Doctor to Consult Reason
High Rheumatologist Potential lupus evaluation.
Normal Primary Care Physician Regular health monitoring.
Low May not need a visit Further evaluation if symptomatic.

 

Anti-dsDNA Test Price

Here are the estimated Anti-dsDNA Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

800-1700

New Delhi

800-1700

Bangalore

850-1700

Hyderabad

800-1700

Kolkata

800-1700

Pune

800-1700

Lucknow

850-1700

Noida

800-1700

Surat

800-1700

Gurugram

850-1700

Patna

800-1700

Chennai

850-1700

Jaipur

800-1700

Ahmedabad

850-1700

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, The Anti-dsDNA Test assesses anti-double-stranded DNA antibodies. High levels may indicate lupus, while low levels don't rule it out. Consult a doctor for interpretation. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Anti-dsDNA antibodies - Wikipedia [1].
  • Anti-dsDNA [2].
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Anti-dsDNA Test FAQ

Can exercise affect Anti-dsDNA levels?

Light exercise is generally fine before the test, but avoid strenuous workouts immediately prior to the blood draw.

What is an Anti-dsDNA test?

An Anti-dsDNA test is a blood test that helps diagnose autoimmune diseases like lupus by measuring antibodies against DNA.

Why is it important to test for Anti-dsDNA?

This test aids in diagnosing and monitoring lupus, enabling timely treatment to manage symptoms and prevent complications.

How is the Anti-dsDNA test performed?

A blood sample is typically collected from a vein in your arm, and the serum is tested for the presence of anti-dsDNA antibodies.

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