Adenosine Deaminase Test To Measure ADA in Pleural Fluid

Adenosine Deaminase Test To Measure ADA in Pleural Fluid

The Adenosine Deaminase Test (ADA) is a medical tool used to detect tuberculosis (TB) infections in the body, particularly in the lungs, aiding in early diagnosis and treatment. It measures ADA levels in bodily fluids.

 

Adenosine Deaminase Test

Here are the basic details of the Adenosine Deaminase Test.

Also Known As ADA Test
Type Blood test or fluid analysis
Purpose To aid in diagnosing tuberculosis (TB) infections
Sample Type Pleural fluid
Preparation No
Fasting No required
Gender Unisex
Age Group All
Normal Value 40 units/L
Reporting Time A few days
Cost 300-600 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

 

Adenosine Deaminase Test Means

It's a diagnostic tool used to detect tuberculosis (TB) by measuring ADA levels in bodily fluids like pleural fluid.

  • ADA Test helps identify TB infections in the lungs, enabling early diagnosis and treatment.
  • This test is performed on blood or various body fluids to assess ADA levels.
  • Typically, there's no need for fasting or special preparation before the ADA test.
  • ADA Test results are usually available within hours to aid in prompt TB diagnosis.

 

Adenosine Deaminase Test Purpose

The purpose of the Adenosine Deaminase Test is to:

  • Adenosine Deaminase Test aids in diagnosing tuberculosis infections.
  • Evaluates ADA levels in pleural or other body fluids.
  • Helps detect TB promptly for timely treatment.
  • Assists in identifying TB in the lungs.
  • Part of TB diagnosis and treatment strategy.

Adenosine Deaminase Test_ Price, Normal Range, Result, Purpose, Meaning and Interpretation - Drlogy Test

 

Adenosine Deaminase Test Preparation

Here is the basic preparation for the Adenosine Deaminase Test.

 

Before Test

  • No specific fasting or dietary restrictions are typically required.
  • Inform your healthcare provider about any medications or medical conditions.
  • Follow any instructions provided by your healthcare team.

 

During Test

  • You may be asked to sit or lie down comfortably.
  • A sample of blood or body fluid will be collected using a syringe or needle.
  • Remain still and follow any guidance from the healthcare provider.

 

After Test

  • You can resume normal activities immediately.
  • You may experience minor discomfort or bruising at the injection site.
  • Await the test results, which are usually available within a few hours to a day.

 

Adenosine Deaminase Test Procedure

Here is the basic Adenosine Deaminase Test Procedure.

  • Collection of blood or body fluid sample (e.g., pleural fluid).
  • Sample sent to a laboratory for ADA level analysis.
  • Results reported to the healthcare provider for interpretation and diagnosis.

 

Adenosine Deaminase Test Result

  • Normal range: 40 units/L for males and females of all ages.
  • Elevated levels suggest possible pleural tuberculosis.
  • Sensitivity 81-100% and specificity 83-100%; false positives due to various conditions like empyemas, lymphomas, and malignant diseases.

 

Adenosine Deaminase Test Normal Range

Here is the normal range of the Adenosine Deaminase Test.

Gender Normal Range (units/L)
Male 40 units/L
Female 40 units/L

 

Adenosine Deaminase Test Interpretation

Here is the Interpretation of the Adenosine Deaminase Test.

ADA Level (units/L) Interpretation
Less than 40 Typically considered within the normal range.
40 - 70 May be slightly elevated, warrants further evaluation.
Above 70 Elevated ADA levels, potential indication of pleural tuberculosis.

Elevated ADA levels, above 70 units/L, may indicate pleural tuberculosis, while values within the normal range (less than 40 units/L) are typically considered normal.

 

Adenosine Deaminase Test High Levels

Here are some possible causes of high Adenosine Deaminase levels:

Causes Description
Tuberculosis (TB) Elevated ADA often indicates pleural TB.
Empyemas Infections leading to fluid accumulation.
Lymphomas Certain types may increase ADA levels.
Malignant Diseases Cancer-related elevations in ADA.
Parapneumonic or Collagen Vascular Disease Inflammatory conditions can affect ADA levels.

High Adenosine Deaminase (ADA) levels can be caused by conditions like tuberculosis, empyemas, lymphomas, malignant diseases, and inflammatory disorders.

 

Adenosine Deaminase Test Low Levels

Here are some possible causes of low Adenosine Deaminase levels:

Causes Description
ADA Deficiency A rare genetic condition leading to low ADA levels, affecting the immune system.
Kidney Disease Reduced ADA production due to impaired kidney function.
Medications Certain drugs may interfere with ADA activity.
Hemolytic Anemia Conditions leading to the breakdown of red blood cells can affect ADA levels.
Nutritional Deficiencies Inadequate intake of essential nutrients can impact ADA production.

Low Adenosine Deaminase (ADA) levels may result from ADA deficiency, kidney disease, medications, hemolytic anemia, or nutritional deficiencies.

 

Specimen Requirements For Adenosine Deaminase Test

Here are the specimen requirements for the Adenosine Deaminase Test.

Specimen

Pleural fluid

Volume

20 mL

Container

Screw-capped container with no preservative.

Collection

The sample should be sent for analysis within one hour after collection.

Storage

Frozen

Sample Stability

Temperature

Period

Frozen

28 days

Causes for Rejection

Specimens other than EDTA whole blood, Mislabeled or unlabeled specimens.

 

Adenosine Deaminase Test is Safe?

ADA Test is generally safe when performed by trained healthcare professionals.

  • Minimal risk of infection or bleeding at the collection site.
  • Rare allergic reactions to local anesthetics may occur.
  • Discuss any concerns with your healthcare provider.

 

When Do You Get Adenosine Deaminase Test Results? 

  • Typically available within a few days.
  • Exact reporting time can vary by laboratory and location.
  • Results should be interpreted by a healthcare provider.

 

Adenosine Deaminase Test Limitation

Here is the basic limitation of Adenosine Deaminase Test.

  • Not definitive for TB diagnosis.
  • Cannot identify drug-resistant TB.
  • Elevated levels have other possible causes.
  • Interpretation requires clinical context.
  • False positives in specific conditions.

 

Adenosine Deaminase Test Risk Factors

Here are some of the risk factors of the Adenosine Deaminase Test.

  • No specific risk factors associated with the test itself.
  • Risks may relate to the underlying conditions prompting the test.
  • Consult with a healthcare provider for personalized risk assessment.

 

Doctor Recommendations After Adenosine Deaminase Test Result

 Here are the Doctor's recommendations or consult a specialist after the Adenosine Deaminase Test.

ADA Test Result Doctor to Visit Reason
High Pulmonologist Investigate possible TB infection.
Normal No specific doctor Interpret based on clinical need.
Low Immunologist Evaluate potential immune disorder.

 

Adenosine Deaminase Test Price

Here are the estimated Adenosine Deaminase Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

500-600

New Delhi

525-600

Bangalore

500-600

Hyderabad

525-600

Kolkata

500-600

Pune

525-600

Lucknow

500-600

Noida

525-600

Surat

525-600

Gurugram

500-600

Patna

525-600

Chennai

500-600

Jaipur

525-600

Ahmedabad

500-600

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, The Adenosine Deaminase Test (ADA) measures ADA levels to aid in diagnosing pleural tuberculosis and other conditions, with various causes for elevated or low results. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Adenosine Deaminase - Wikipedia [1].
  • Adenosine Deaminase (ADA) Level in Tubercular Pleural ... - NIH [2].
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Adenosine Deaminase Test FAQ

What is Adenosine Deaminase test for?

The Adenosine Deaminase (ADA) test is used to diagnose conditions such as tuberculosis (TB) and evaluate lymphocytic pleural effusions, aiding in the differentiation of various diseases causing pleural fluid accumulation.

What does ADA positive mean?

ADA positive indicates elevated levels of Adenosine Deaminase, suggesting an increased immune response. In the context of TB diagnosis, a positive ADA result is indicative of Mycobacterium tuberculosis infection or other granulomatous diseases.

What is ADA level in TB?

ADA levels in TB are typically elevated. A threshold level (usually >40 U/L) is often considered diagnostic, aiding in the differentiation of TB from non-TB causes of pleural effusion.

What happens if ADA is high?

High ADA levels suggest an active cell-mediated immune response. In TB, this indicates an increased likelihood of Mycobacterium tuberculosis infection. Elevated ADA may contribute to inflammation, leading to symptoms like fever and cough.

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