ACTH (Cosyntropin) Stimulation Test

The ACTH Stimulation Test is a medical procedure that helps doctors check the health of your adrenal glands and hormone production. It's important for diagnosing certain health conditions.

ACTH Stimulation Test

Here are the basic details of the ACTH Stimulation Test.

*Price range may vary as per location, lab type, and procedure of lab test.

ACTH Stimulation Test Means

The ACTH Stimulation Test assesses adrenal gland function by measuring cortisol response to synthetic ACTH.

• It helps diagnose adrenal insufficiency, Addison's disease, and pituitary issues.
• A blood sample is taken before and after ACTH injection to evaluate cortisol levels.
• The test aids in confirming or ruling out hormone-related disorders.
• ACTH Stimulation Test is crucial for identifying adrenal health and guiding appropriate medical treatment.

ACTH Stimulation Test Purpose

The purpose of the ACTH Stimulation Test is to:

• Evaluates adrenal gland function and cortisol response to diagnose adrenal disorders.
• It helps diagnose conditions like Addison's disease and pituitary problems.
• Measures the body's ability to produce cortisol when stimulated by ACTH.
• Essential for identifying hormone-related health issues.
• Guides doctors in providing appropriate treatment for adrenal and pituitary disorders.

ACTH Stimulation Test Preparation

Here is the basic preparation for the ACTH Stimulation Test.

Before Test

• Follow any fasting instructions provided by your healthcare provider.
• Inform your doctor about any medications you're currently taking.
• Be prepared for a blood draw.

During Test

• A blood sample is taken initially.
• Synthetic ACTH is injected into your muscle or vein.
• Additional blood samples are collected at specified intervals.

After Test

• Rest and resume normal activities unless advised otherwise by your healthcare provider.
• Results will be discussed in a follow-up appointment with your doctor.

ACTH Stimulation Test Procedure

Here is the basic ACTH Stimulation Test Procedure.

• Blood sample taken initially.
• Synthetic ACTH injected into muscle or vein.
• Additional blood samples collected at specified intervals.
• Cortisol levels measured in each sample.
• Results used to diagnose adrenal insufficiency or pituitary issues.

ACTH Stimulation Test Result

• Normal result: Post-ACTH cortisol levels exceed 20 mcg/dL or 500-600 nmol/L.
• Abnormal result: Indicates possible adrenal insufficiency. ACTH levels help differentiate primary and central causes.
• Adequate cortisol response: A rise of at least 7-10 μg/dL at 60 minutes rules out primary adrenal insufficiency.

ACTH Stimulation Test Normal Range

Here is the normal range of the ACTH Stimulation Test.

ACTH Stimulation Test Interpretation

Here is the Interpretation of the ACTH Stimulation Test.

ACTH Stimulation Test interprets cortisol response, with normal results > 500-600 nmol/L and abnormal indicating adrenal insufficiency possibilities.

ACTH Stimulation Test High Levels

Here are some possible causes of high ACTH Stimulation levels:

High ACTH Stimulation Test levels can indicate primary adrenal insufficiency due to Addison's disease, pituitary adenoma, or ectopic ACTH-producing tumors.

ACTH Stimulation Test Low Levels

Here are some possible causes of low ACTH Stimulation levels:

Low ACTH Stimulation Test levels suggest secondary adrenal insufficiency, often due to pituitary dysfunction or excessive corticosteroid use.

Specimen Requirements For ACTH Stimulation Test

Here are the specimen requirements for the ACTH Stimulation Test.

ACTH Stimulation Test is Safe?

ACTH Stimulation Test is generally considered safe when performed by trained professionals.

• Minor discomfort from needle insertion.
• Rare risks include infection or bleeding at the injection site.
• Benefits outweigh potential risks for diagnostic purposes.
• Discuss any concerns with your healthcare provider.

When Do You Get ACTH Stimulation Test Results? 

• Results typically available within a hour, depending on the laboratory.
• Timing may vary based on the healthcare facility and location.
• Discuss the reporting time with your healthcare provider for specifics.

ACTH Stimulation Test Limitation

Here is the basic limitation of ACTH Stimulation Test.

• May not detect early or mild adrenal insufficiency.
• Some medications can interfere with test results.
• Results can be influenced by stress and other factors.
• False negatives or positives are possible, requiring further evaluation.
• May not differentiate between primary and secondary adrenal insufficiency.

ACTH Stimulation Test Risk Factors

Here are some of the risk factors of the ACTH Stimulation Test.

• Minimal risk when performed by trained professionals.
• Infection or bleeding at the injection site possible.
• Rare adverse reactions to ACTH injection (e.g., allergic reactions).
• Risks higher with unqualified personnel or improper procedure.
• Discuss specific concerns with your healthcare provider beforehand.

Doctor Recommendations After ACTH Stimulation Test Result

 Here are the Doctor's recommendations or consult a specialist after the ACTH Stimulation Test.

After an ACTH Stimulation Test, consult an endocrinologist for high or low results indicating potential adrenal issues.

ACTH Stimulation Test Price

Here are the estimated ACTH Stimulation Test Prices in India with different top cities:

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

Summary

Overall, After an ACTH Stimulation Test, see an endocrinologist for guidance on adrenal health based on test results, ensuring comprehensive care. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

Reference

• ACTH Stimulation Test - Wikipedia [1].
• ACTH Stimulation Test for the Diagnosis of Secondary ... - NIH [2].