High estradiol (E2) levels in both men and women can have various effects depending on the individual's sex, stage of life, and overall hormonal balance. Estradiol is an important hormone involved in reproductive health, bone health, cardiovascular health, and other physiological functions. However, excessively high estradiol levels can be associated with certain symptoms and health risks. In males, high estradiol levels can potentially lead to symptoms such as gynecomastia (breast enlargement), water retention, mood swings, decreased libido, and potential impact on sexual function. In females, high estradiol levels can cause symptoms such as breast tenderness, bloating, mood swings, heavy or irregular menstrual periods, and potential impact on fertility. It's important to note that symptoms alone are not sufficient to diagnose high estradiol levels. Clinical evaluation, including hormone level testing and assessment by a healthcare professional experienced in hormone management or endocrinology, is essential for accurate diagnosis and appropriate management of hormonal imbalances. If you have concerns about your estradiol levels or experience related symptoms, it is recommended to seek medical advice for proper evaluation and guidance.