Testosterone To Estradiol Ratio Calculator - T/E2 Ratio

Testosterone To Estradiol Ratio Calculator Overview

• The Testosterone To Estradiol Ratio Calculator also known as the T/E2 Ratio Calculator helps you to find the 
• Testosterone To Estradiol Ratio Calculator that predicts parameters linked to male health aspects, primarily associated with sexual functions. 
• The values needed for the estimation are free testosterone (T) and estradiol (E2) concentrations. 
• You can also use the calculator to convert estradiol and testosterone measurement units.

 

Steps To Calculate Testosterone To Estradiol Ratio

1. Enter Testosterone Value (ng /dL)
2. Enter Estradiol Value (pg/ dL)
3. Check the Testosterone To Estradiol Ratio

 

Testosterone To Estradiol Ratio Formula

Category	Formula
Testosterone To Estradiol Ratio	T/E2 = Testosterone / Estradiol

 

Good Testosterone To Estradiol Ratio

There are no fixed values for the T/E2 ratio to be considered healthy. It's considered good as long as the individual hormone levels are within normal ranges:

Testosterone (T)	300-1000 ng/dL (10-35 nmol/L)
Estradiol (E2)	14-55 pg/mL (50-200 pmol/L)

 

 

What is Testosterone to Estradiol Ratio

According to scientific research, the T/E2 ratio is a parameter linked to various aspects of male health:

 

• Male coronary heart disease development.
• Development of ameliorated depressive symptoms
• Atherosclerosis development.
• Infertility treatment prognosis.
• Prediction of low libido and erectile dysfunctions.

 

T/E2 Ratio

• The testosterone to estradiol ratio, also known as the testosterone to estrogen ratio is one of the most commonly determined parameters of male sexual function. 
• The T/E2 ratio uses the testosterone concentration in ng/dL and the estradiol concentration in pg/mL.

 

Normal Value For Testosterone To Estradiol Ratio

• Whilst a normal reference range for the T/E2 ratio has not been defined, a value is considered to be acceptable as long as the testosterone and estradiol/estrogen concentrations are within their normal range.

Parameter	Normal values
Testosterone	300-1000 ng/dL
Estradiol	14-55 pg/mL
T/E2	Not Defined

 

Testosterone Estradiol Unit For Measurement

• The most frequently used testosterone unit of measurement is ng/dL (nanogram per deciliter), and the international standard is nmol/L (nanomole per liter).

 

The conversion of its concentration is calculated by using this formula:

1 nmol/L = 1000 pmol/L = 28.85 ng/dL

and

1 ng/dL = 0.03466 nmol/L = 34.66 pmol/L

 

• You could expect the conversion of estradiol units to be conducted in the same way. 
• However, the concentration of every substance is calculated differently. 

 

For estradiol, you do it this way:

1 pmol/L = 0.2724 pg/mL

and

1 pg/mL = 3.6713 pmol/L

 

Importance of Testosterone and Estradiol in Sexual Health

• The effects and roles of testosterone in male health are well known whilst those of estradiol (modulating libido, erectile function, and spermatogenesis) are less known. 
• Low testosterone and elevated estrogen were found to increase the incidence of erectile dysfunction independently of one another.
• Zheng et al. studied the relationship between the T/E2 ratio and chronic heart disease (CHD) on a sample of 55 male CHD patients and 60 healthy age-matched controls. 
• The study found that the balance of the T/E2 ratio has a crucial role in modulating the effect of androgens on CHD in males.

 

Sex Hormones: Testosterone and Estradiol

• Testosterone and estradiol are the principal hormones that control the sexual characteristics of males and females, respectively. 
• They are both steroids, that is they are based upon the general pattern of the 17-carbon ring system shown below. 
• This is the same structure used by other biologically important steroid molecules, including drugs, poisons, bile acids, vitamins, and hormones. 
• Examples are cortisone (which controls carbohydrate metabolism and is used therapeutically to relieve symptoms of inflammation), Vitamin D2 (which is essential for calcium metabolism and prevents rickets), digitoxigenin (which is extracted from the digitalis plant and used to regulate heart rates)
• The steroid structure. The ring carbons are numbered 1 to 17, and the 4 rings are labeled A-D as indicated. Side chain carbons are numbered from 18 upwards. 
• The biological activity of the different steroids depends on the nature of the substituents attached to this basic structure, and even slight changes can dramatically alter the biological effect of the molecule.
• The steroid hormones are mostly non-polar molecules that can readily pass through cell membranes. 
• They work by entering the cell and binding to a receptor site on a large protein molecule. 
• This steroid-receptor unit is then transferred to the nucleus of the cell where it activates specific genes. 
• This means that steroid hormones create effects over a much slower timescale (hours or days) than those of other non-hormonal steroids (such as cortisone, digitoxigenin, etc), which instead act on the surface of the cell membrane and cause effects almost instantly.

 

Testosterone - Male Sex Hormone

• One of the results of puberty in boys is the initiation of testosterone secretion from special cells within the testes. 
• This then controls the development of all the masculine secondary sexual characteristics, such as an enlargement of the skeleton, deepening of the voice, the growth and pattern of body hair, and the maturation of the sexual organs. 
• It has also been linked to changes in behavior patterns, particularly those involving heightened aggression and competitiveness.

 

Estradiol - Female Sex Hormones

• The main female hormones are known collectively as estrogens. 
• There are a number of these, all of which have a similar structure, examples of which include estradiol and estrone. 
• They differ from testosterone only slightly, by having one less -CH3 group at the 19-carbon position, the C=O group at the C-3 position being reduced to -OH, and the A-ring being fully delocalized. 
• It is amazing to realize that these slight changes in molecule structure are all that differentiate a male from a female.
• As with testosterone in boys, these hormones are released at puberty in girls, and maintain the female secondary sexual characteristics throughout the woman's fertile life. until menopause, whereupon their concentration decreases rapidly. 
• They work by acting upon RNA, which, in turn, controls how the instructions in DNA concerning growth are to be interpreted.

 

Low T/E2 ratio Effects

• low T/E2 ratios in patients with the manifest atherosclerotic disease were associated with increased systemic inflammation and an increased risk of future major adverse cardiac events (MACE). 
• These effects were also stronger in males with elevated BMI so there may be a link to aromatase activity in white fat tissues.

 

Summary

The Testosterone to Estradiol Ratio Calculator calculates the ratio of testosterone to estradiol levels in the body. Check more sexual medical calculators like this to solve your daily problems on Drlogy Calculator to get the exact solution.

 

Reference

• Total Testosterone to Estradiol Ratio as a Predictor Marker [1].
• Free & Bioavailable Testosterone calculator [2].