Why is Fibrinogen high in nephrotic syndrome?

In nephrotic syndrome, a kidney disorder characterized by increased protein leakage into urine, Fibrinogen levels can be elevated. The underlying mechanisms are complex. In nephrotic syndrome, there is a loss of proteins, including albumin, through the damaged kidney's filtration barrier. This loss leads to a decrease in oncotic pressure, which can trigger the liver to produce and release more Fibrinogen into the bloodstream. The elevated Fibrinogen levels in nephrotic syndrome are part of the body's response to compensate for protein loss and maintain hemostasis. However, it's important to note that Fibrinogen elevation is just one aspect of the complex pathophysiology of nephrotic syndrome. Managing nephrotic syndrome typically involves addressing the underlying kidney damage, managing proteinuria, and employing specific treatment strategies to reduce protein leakage and minimize complications.