High creatine kinase (CK) levels are typically caused by muscle damage or injury. Some common causes include conditions like myocardial infarction (heart attack), muscular dystrophy, rhabdomyolysis (severe muscle breakdown), polymyositis (inflammatory muscle disease), dermatomyositis, and certain metabolic disorders. Additionally, activities or events that result in muscle trauma, such as strenuous exercise, heavy weightlifting, or physical injuries, can also lead to elevated CK levels. Identifying the underlying cause of high CK levels requires proper medical evaluation and diagnostic testing to guide appropriate treatment and management.