Several factors can affect PDW (Platelet Distribution Width). PDW values are influenced by platelet production, destruction, and various medical conditions. Conditions that can affect PDW include platelet disorders, bone marrow disorders, nutrient deficiencies (such as vitamin B12 or folate deficiency), liver disease, immune thrombocytopenic purpura (ITP), or certain cancers. Additionally, medications, infections, inflammation, and recent platelet transfusions can impact PDW values. However, it's important to note that PDW alone cannot provide a definitive diagnosis. If you have concerns about your PDW or any abnormal blood test results, it is recommended to consult with a healthcare professional. They can evaluate your complete medical history, order additional tests if necessary, and provide appropriate guidance based on a comprehensive assessment of your condition.