What causes Digoxin toxicity?

Digoxin toxicity can be caused by several factors. The most common cause is an excessive accumulation of Digoxin in the bloodstream due to an overdose or impaired elimination. Kidney dysfunction, which affects Digoxin clearance from the body, can contribute to toxicity. Drug interactions can also increase Digoxin levels by inhibiting its metabolism or excretion. Certain medical conditions, such as hypokalemia (low potassium levels) or hypomagnesemia (low magnesium levels), can increase the risk of Digoxin toxicity. Additionally, individual factors such as age, genetic variations in drug metabolism, and sensitivity to Digoxin can influence the likelihood of toxicity. To prevent Digoxin toxicity, it is crucial to monitor Digoxin levels regularly, adjust the dosage appropriately, and be cautious with potential drug interactions or underlying conditions that can increase the risk.