VLDL (Very Low-Density Lipoprotein) size refers to the diameter or particle size of VLDL particles. Larger VLDL particles are generally associated with a higher risk of cardiovascular disease. However, it's important to note that VLDL particle size is not typically measured in routine clinical practice. Instead, VLDL cholesterol levels are used as an indirect marker of VLDL particle concentration. High VLDL cholesterol levels are generally considered detrimental to cardiovascular health, as they indicate an increased amount of triglyceride-rich particles being transported in the bloodstream. Managing high VLDL cholesterol levels through lifestyle modifications and, if necessary, medication can help mitigate the associated risks. Consulting with a healthcare professional is crucial for personalized guidance and interpretation of lipid profile results.