C-reactive Protein (CRP) Test

C-reactive Protein (CRP) Test

What is C-reactive Protein (CRP)?

C-reactive protein (CRP) is an annular pentameric protein found in blood plasma produces by the liver whose concentrations rise in response to inflammation.


CRP is an acute-phase protein of liver origin that increases following interleukin-6 secretion by T cells and macrophages.


High CRP levels can also indicate that there’s inflammation in the arteries of the heart, however, it extremely nonspecific test because it can be elevated in many inflammatory conditions.


What is a c-reactive Protein (CRP) Test?

A c-reactive protein (CRP) test measures the level of c-reactive protein in your blood.


Normally, we have low levels of c-reactive protein in our blood but it can increase in response to inflammation.


The c-reactive protein (CRP) test helps to determine whether symptoms are related to an inflammatory or non-inflammatory condition & if symptoms are inflammatory then the inflammation is acute (severe and sudden, such as with an allergic reaction) or chronic (persistent, such as with diabetes).


CRP Test also known as:

  • C-Reactive Protein (CRP)
  • CRP (C-Reactive Protein)
  • CRP, Serum
  • C-Reactive Protein, Serum
  • Protein, C-Reactive


What is it used for?

The CRP test may be used to find or monitor wide medical conditions that cause inflammation. These include:

  • Viral infections
  • Allergic reaction
  • Asthma, Bronchitis & Pneumonia
  • Autoimmune diseases like lupus & rheumatoid arthritis
  • Bacterial infection
  • Cancer
  • Celiac disease
  • Connective tissue disease
  • COPD (Chronic obstructive pulmonary disease)
  • Diabetes
  • Heart attack & Heart disease
  • High blood pressure
  • Inflammatory bowel disease (IBD)
  • Major trauma
  • Pancreatitis
  • Pelvic inflammatory disease (PID)
  • Systemic fungal infections
  • Vascular diseases like vasculitis & aortic aneurysm
  • Bone Infection called osteomyelitis


What happens during a CRP test?

A phlebotomist will take a blood sample from a vein in your arm, using a small needle after applying a snug rubber band around the upper arm.


After the small needle is inserted, a small amount of blood will be collected into a vial or test tube.


You may feel a little sting when the small needle goes in or out. This process usually takes less than 2 - 5 minutes.


 CRP Test Sample Type, Quantity, Storage & Timing

Primary Sample Blood
Sample Quantity 2.0 ml
Storage Refrigerator
Test Timing 2 hrs


CRP Test Preparation

Inform your doctor if you are on any medications, have underlying medical conditions, or have any allergies before your CRP test.


The patients don't need any special preparations required for the CRP test.


Fasting is not required before the sample collection for the CRP test.


Are there any risks to the CRP Test?

There is very little risk including oozing at the draw site, bruising or mild tenderness at the site, to having a blood test.


You may have a slight bruise or pain at the spot where the needle was put in, but most symptoms go away very quickly.


CRP Blood Test Result Interpretation?

Less than 3 mg/L: Normal level seen in most healthy adults


3 to 10 mg/L: Normal or minor elevation

  • Obesity
  • Pregnancy
  • Depression
  • Diabetes
  • Common cold
  • Gingivitis
  • Periodontitis
  • Sedentary lifestyle
  • Cigarette smoking


10 to 100 mg/L: Moderate elevation

Systemic inflammation such as

  • Rheumatoid arthritis (RA)
  • Systemic lupus erythematosus (SLE)
  • Autoimmune diseases
  • Malignancies
  • Myocardial infarction
  • Pancreatitis
  • Bronchitis


More than 100 mg/L: Marked elevation

  • Acute bacterial infections
  • Viral infections
  • Systemic vasculitis
  • Major trauma


More than 500 mg/L: Severe elevation

Systemic wide spread bacterial infections


If you have questions about your results, talk to your health care provider.


CRP normal range (Reference Values) :

Gender Age Value
Male All Age <3 mg/L
Female All Age <3 mg/L


Normal Range may be vary from lab to lab as per test mehods used.


CRP Related Tests:

  • High-sensitivity C-reactive Protein (hs-CRP)
  • Erythrocyte Sedimentation Rate (ESR)



  • A CRP test perform for detecting a substance called C-reactive protein to measure general inflammation in the body.
  • The CRP test cannot tell you where or why inflammation is occurring, but it can point to possible causes.
  • The patients no need to any special preparations required for the CRP test.
  • Normal range of C-reactive protein (CRP) is <3 mg/L in all age & gender.


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