7 Advancements & Future Research Prospects in Arthritis Treatment

Arthritis is not a curable disease but there is hope that there will be better therapies to deal with this disorder that will have a much more sustained effect on joint health.

With research going on in the medical field, the field has become dynamic and every now and then we are discovering new inventions to deal with diseases and treatments.

7 Advancements & Future Research Prospects in Arthritis Treatment

Here are Some of the advancements that are under study for the treatment of arthritis are listed below:

1. Biologic therapies:

• Arthritis is a disorder of pain and inflammation of the joints.
• There are several biological pathways that are impaired and hence this pain and inflammation is chronic in nature.
• Biologic therapies include producing genetically engineered proteins targeting the particular biological pathway that might be involved in the pain and inflammation of the joint.
• These proteins directly target the biological pathway and inhibit the components responsible for inflammation.

2. Precision Medicine

• Precision medicine targets to develop medication according to a particular individual i.e. is tailor-made medicine.
• This includes identifying the genetic makeup of an individual and developing a medicine that is suitable for him.
• Although the process for this kind of procedure might not be economical but it definitely has great potential in treatment as it ensures that the medicine will work for the particular individual.

3. Stem Cell Therapy

• Stem cell therapy includes extraction of stem cells from the patient own body or through a donor and stem cells are then cultured and introduced inside the patients joints via intra-articular injection. 
• Evidence has been found that these stem cells support the regeneration of the cartilage, have immunomodulatory effects and also act as precursors for various cells and secret substances that help in maintaining the health of the joint.
• Studies are being conducted to develop nano particles or vesicles of stem cells that are coated with polymer and survive well in the impaired joint space.
• Therefore, deliver a long lasting and sustained effect on the joint health.

4. Gene Therapy

• Gene therapy involves treating the malfunctioning gene or adding a new gene to normalize the functions of body.
• The major drawback in the development of new therapies the has been the impaired metabolism of the joints, if a therapeutic product is injected into the joint it is deteriorated and is unable to show a sustained effect.
• This drawback can be overcome by gene therapy, the gene that signals the synthesis of the desired protein is injected into the joint space and therefore, can have a long-lasting effect on the inflammation in the joint.

5. Tissue engineering:

Tissue engineering aims to regenerate cartilage or repair the tissue by transplanting external progenitor population that mimic the action of native autologous chondrocytes. It requires 3 ingredients:

• Matrix to form structure  
• Cells to mimic action 
• Signal for cells to mimic action

The implanted tissue scaffolds should be able to blend in with the natural tissue.

• These scaffolds. might be synthetic or natural.
• These should be biocompatible, customizable, and biomimetic.
• These scaffolds might be generated via a variety of mechanisms such as 3D Printing, hydrogels, supercritical fluid technology, electrospinning, and weaving.

6. Nutraceuticals and Dietary Supplements

• Nutraceuticals and dietary supplements are commonly used for the management of arthritis.
• Advancements in these have contributed to enhancing its safety and efficacy.
• Innovations to these include enhancement of absorption and therefore better bioavailability, targeted therapies designed for specific types of arthritis, combination of supplements to enhance the action and clinical efficacy.
• Clinical research helps in approving their effects and advancement in the regulatory standards ensures the enhancement of quality and safety.
• These advancements contribute to improved management of arthritis and boost the quality of life of arthritis patients.

7. Digital Health Technologies

• The advancement in digital health technologies has enhanced the reach of health facilities.
• Some of the recent advancements include

Continued research and clinical validation are crucial for translating these innovations into mainstream clinical practice.

Arthritis Overview & Treatment Management Guide

Check 5 step detailed guide on Arthritis Overview & Treatment Management.

Conclusion

These advancements underscore a dynamic landscape in arthritis research, offering hope for more effective therapies and improved quality of life for patients.

 

Check Drlogy's Arthritis Overview & Treatment Management Guide for detailed arthritis treatment information and solution related to this diseases.

References

• Akhondzadeh, S. (2014). Personalized Medicine: A Tailor Made Medicine. Avicenna Journal of Medical Biotechnology, 6(4), 191. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224657/
• Dang, A., Arora, D., & Rane, P. (2020). Role of digital therapeutics and the changing future of healthcare. Journal of Family Medicine and Primary Care, 9(5), 2207. https://doi.org/10.4103/JFMPC.JFMPC_105_20
• Li, X., Shen, L., Deng, Z., & Huang, Z. (2023). New treatment for osteoarthritis: Gene therapy. Precision Clinical Medicine, 6(2). https://doi.org/10.1093/PCMEDI/PBAD014
• Liu, Y., Wang, M., Luo, Y., Liang, Q., Yu, Y., Chen, F., & Yao, J. (2021). Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach. Gels, 7(4). https://doi.org/10.3390/GELS7040263
• Puri, V., Nagpal, M., Singh, I., Singh, M., Dhingra, G. A., Huanbutta, K., Dheer, D., Sharma, A., & Sangnim, T. (2022). A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges. Nutrients, 14(21). https://doi.org/10.3390/NU14214637
• Raychaudhuri, S., & Raychaudhuri, S. (2009). BIOLOGICS: TARGET-SPECIFIC TREATMENT OF SYSTEMIC AND CUTANEOUS AUTOIMMUNE DISEASES. Indian Journal of Dermatology, 54(2), 100. https://doi.org/10.4103/0019-5154.53175
• Yang, X., Li, S., Ren, Y., Qiang, L., Liu, Y., Wang, J., & Dai, K. (2022). 3D printed hydrogel for articular cartilage regeneration. Composites Part B: Engineering, 237, 109863. https://doi.org/10.1016/J.COMPOSITESB.2022.109863