The direct Antiglobulin test (DAT) is used to detect the presence of antibodies or complement proteins bound to the surface of red blood cells, indicating immune-mediated hemolysis.
What does a positive DAT indicate?
A positive DAT suggests the presence of antibodies or complement on red blood cells, pointing to immune-mediated hemolytic anemia. It helps diagnose conditions like autoimmune hemolytic anemia.
What is the difference between DAT and Coombs test?
The terms DAT (direct Antiglobulin test) and Coombs test are often used interchangeably. However, the DAT specifically refers to the test detecting antibodies or complement on RBCs, while Coombs test encompasses both direct and indirect tests.
What is the purpose of a DAT test?
The DAT is crucial for diagnosing autoimmune hemolytic anemia and hemolytic disease of the newborn. It aids in identifying antibodies or complement proteins that may lead to the destruction of red blood cells.
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