Glucose Tolerance Test For Diabetes and Prediabetes

Glucose Tolerance Test For Diabetes and Prediabetes

A Glucose Tolerance Test, often referred to as GTT, is a medical evaluation used to assess how your body processes sugar (glucose). By measuring blood sugar levels before and after consuming a sugary drink, this test helps diagnose conditions like diabetes and prediabetes.

 

Glucose Tolerance Test

Here are the basic details of the Glucose Tolerance Test.

Also Known As GTT, OGTT Test
Type Blood Test
Purpose Detect Diabetes & Prediabetes
Sample Type Serum
Preparation Fasting (overnight)
Fasting Required
Gender All genders
Age Group Adults, Children
Normal Value <140 mg/dL (after 2 hours)
Reporting Time Few business days
Cost 500 - 1500 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

 

Glucose Tolerance Test Means

A Glucose Tolerance Test measures how your body processes glucose (sugar).

  • It's used to diagnose prediabetes and diabetes.
  • You fast for at least 8 hours before the test.
  • You drink a sweet glucose solution, and blood samples are taken at intervals.
  • Results help determine your body's ability to regulate blood sugar.

 

Glucose Tolerance Test Purpose

The purpose of the Glucose Tolerance Test is to:

  • Evaluates the body's ability to process glucose.
  • Detects prediabetes and diabetes.
  • Screens individuals at risk for diabetes.
  • Diagnoses gestational diabetes in pregnant women.
  • Assesses how the body handles sugar intake.

Glucose Tolerance Test Price, Normal Range, Result, Purpose, Meaning and Interpretation - Drlogy Test

 

Glucose Tolerance Test Preparation

Here is the basic preparation for the Glucose Tolerance Test.

 

Before Test

  • Your healthcare provider will typically ask you to fast for at least 8 hours (usually overnight) before the test.
  • It's essential to follow the fasting instructions, which means no food or drinks except for water during the fasting period.
  • Inform your healthcare provider about any medications you're taking, as some may need to be temporarily stopped before the test.

 

During Test

  • You'll have your blood drawn after the initial fasting period.
  • After the first blood draw, you'll be given a sweet glucose solution to drink.
  • Blood samples will be collected at regular intervals (usually every 30 minutes to 2 hours) after drinking the glucose solution.
  • You may need to remain at the testing facility during this time.

 

After Test

  • Once the blood samples are collected, you can resume normal activities and eat.
  • You may experience mild discomfort at the needle insertion site, but this should quickly resolve.
  • Await the laboratory to analyze the glucose tolerance test results.
  • Follow up with your healthcare provider to discuss the results and any necessary next steps, such as diabetes management or further testing.

 

Glucose Tolerance Test Procedure

Here is the basic Glucose Tolerance Test Procedure.

  • You'll be asked to fast for at least 8 hours (usually overnight).
  • A healthcare professional will draw a fasting blood sample.
  • You'll then be given a sweet glucose drink to consume.
  • Blood samples are taken at regular intervals (typically every 30 minutes to 2 hours) after drinking the glucose solution.
  • During the test, you should remain at the testing site.
  • After the final blood sample is collected, you can usually resume normal activities and eat.

The test measures how your body processes glucose and helps diagnose conditions like prediabetes and diabetes.

 

Glucose Tolerance Test Result

Here's how to interpret Glucose Tolerance Test result values for a non-medical person in 4 short bullet points:

  • Normal Result: A normal result typically shows that your blood glucose levels remain within a healthy range after consuming a sugary drink. 
  • Prediabetes: If your blood glucose levels rise higher than normal but not high enough to be considered diabetes, it may indicate prediabetes.
  • Diabetes: Elevated blood glucose levels throughout the test may indicate diabetes. Diabetes is a chronic condition where your body struggles to regulate blood sugar, which can lead to various health issues.
  • Consult Your Doctor: It's crucial to discuss your test results with a healthcare provider. 

 

Glucose Tolerance Test Normal Range

Here is the normal range of the Glucose Tolerance Test

Time After Glucose Intake Normal Blood Glucose Level
Fasting (before intake) Less than 100 mg/dL
1 hour after intake Less than 200 mg/dL
2 hours after intake Less than 140 mg/dL
3 hours after intake Less than 125 mg/dL

 

Glucose Tolerance Test Interpretation

Here is the Interpretation of the Glucose Tolerance Test.

Time After Glucose Intake Blood Glucose Level Interpretation
Fasting (before intake) Less than 100 mg/dL Normal
1 hour after intake Less than 200 mg/dL Elevated (possible prediabetes)
2 hours after intake Less than 140 mg/dL Normal
3 hours after intake Less than 125 mg/dL Normal

 

Glucose Tolerance Test High Levels

Here is the impact of possible high leveles for a Glucose Tolerance Test (GTT) result.

High GTT Result Possible Implication
Elevated Glucose Risk of prediabetes/diabetes
Impaired Tolerance Glucose metabolism issue
Diabetes High blood sugar levels
Insulin Resistance Difficulty using insulin

 

Glucose Tolerance Test Low Levels

Here are possible low levels for a Glucose Tolerance Test (GTT) result.

Low GTT Result Possible Implication
Hypoglycemia Very low blood sugar levels
Reactive Response to high-carb meal
Normal Healthy glucose metabolism
Efficient Effective insulin utilization

 

Specimen Requirements For Glucose Tolerance Test

Here are the specimen requirements for the Glucose Tolerance Test.

Specimen

Serum

Volume

1 ml

Container

Red-top tube or gel-barrier tube

Collection

Patient should be instructed not to eat or drink anything except water for at least eight hours and not more than 14 hours before the test.

Storage

Maintain specimen at room temperature.

Sample Stability

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Stressed patient (surgery, infection, corticosteroids) should not have GTT.

 

Glucose Tolerance Test is Safe?

The Glucose Tolerance Test (GTT) is generally safe, and here are two key points:

  • Common Test: GTT is a commonly performed test with a low risk of complications.
  • Minor Side Effects: Some individuals may experience mild side effects like nausea or dizziness during the test, but these typically resolve quickly.

 

When Do You Get Glucose Tolerance Test Results? 

You can expect Antinuclear Antibody (ANA) test results in the following manner:

  • Turnaround Time: Results may be available within a few business days.
  • Delivery Method: Doctors may share results over the phone, by mail, or electronically.

 

Glucose Tolerance Test Limitation

Here is the basic limitation of Glucose Tolerance Test.

  • Results can vary based on individual factors.
  • Requires fasting and multiple blood draws.
  • Discomfort from drinking glucose solution.
  • Potential for false positives or negatives.
  • May not diagnose all cases of diabetes.

 

Glucose Tolerance Test Risk Factors

Here are some of the risk factors of the Glucose Tolerance Test.

  • Family history of diabetes
  • Obesity or overweight
  • Sedentary lifestyle
  • Gestational diabetes during pregnancy
  • Polycystic ovary syndrome (PCOS)
  • High blood pressure
  • High cholesterol levels
  • Previous history of prediabetes
  • Age over 45

 

Doctor Recommendations After Glucose Tolerance Test Result

 Here are the Doctor's recommendations or consult a specialist after the Glucose Tolerance Test.

Test Result Doctor to Visit Reason
High Hematologist Evaluate potential health issues
Normal No specific doctor Monitor general health
Low Hematologist Investigate low antibody levels

 

Glucose Tolerance Test Price

Here are the estimated Glucose Tolerance Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

100-200

New Delhi

150-200

Bangalore

100-200

Hyderabad

150-200

Kolkata

100-200

Pune

150-200

Lucknow

100-200

Noida

150-200

Surat

150-200

Gurugram

100-200

Patna

150-200

Chennai

100-200

Jaipur

150-200

Ahmedabad

100-200

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, Glucose Tolerance Test is safe for assessing how the body processes glucose, especially in cases of prediabetes and diabetes, but it has limitations and may not capture all nuances of glucose metabolism. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Glucose Tolerance Test - Wikipedia [1].
  • Glucose Tolerance Test - NIH [2].

 

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Glucose Tolerance Test FAQ

What is a normal GTT level?

Typically, a normal fasting glucose level for a Glucose Tolerance Test (GTT) is less than 100 mg/dL.

What is a normal OGTT level in pregnancy?

A normal Oral Glucose Tolerance Test (OGTT) level during pregnancy is fasting <92 mg/dL, 1-hour <180 mg/dL, and 2-hour <153 mg/dL.

What is the principle of the glucose tolerance test?

The GTT measures how well the body metabolizes glucose. After fasting, glucose is ingested, and blood samples are taken at intervals to assess how effectively the body clears glucose.

Why 75g of glucose is used in OGTT?

The 75g glucose load is used to challenge the body's ability to handle a larger amount of glucose, simulating the stress of a meal, providing a more comprehensive assessment.

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