What is the cause of HER2-positive breast cancer?

The cause of HER2-positive breast cancer is not fully understood. The overexpression or amplification of the HER2 gene in breast cancer cells occurs due to molecular and genetic abnormalities specific to the tumor cells themselves. These abnormalities can arise from various factors, including gene mutations, chromosomal alterations, or other molecular changes. However, the exact causes of HER2 overexpression or amplification are complex and not well-defined. It's important to note that HER2 positivity is not caused by external factors, lifestyle choices, or specific behaviors. It is an inherent characteristic of the cancer cells. Accurate HER2 testing is performed on breast cancer samples to identify patients who may benefit from targeted therapies specifically designed to inhibit the HER2 protein and improve treatment outcomes. Ongoing research aims to further understand the underlying mechanisms and potential causes of HER2 overexpression to develop more effective treatment approaches for HER2-positive breast cancer. It's important to consult with a healthcare provider for the most up-to-date information on the causes and treatment options for HER2-positive breast cancer based on individual circumstances.