How is thalassemia hemolytic?

Thalassemia can be hemolytic or non-hemolytic, depending on the specific type and severity. Hemolytic thalassemia occurs when there is significant red blood cell breakdown or destruction. In certain types of thalassemia, such as beta thalassemia major or intermedia, the abnormal hemoglobin production or imbalance leads to red blood cell damage and subsequent hemolysis. The hemolysis results in a deficiency of functional red blood cells, leading to anemia and associated symptoms. However, it's important to note that not all types of thalassemia are hemolytic. Thalassemia can present with a wide spectrum of severity, ranging from mild anemia to severe hemolytic anemia, and the specific manifestations can vary depending on the type and genetic mutations involved.